Asmita Prabhune

Asmita Prabhune

Biochemical Science Division

About Me

The work going on in my lab covers a whole spectrum of topics from basic microbiology to nanotechnology. There is a well establishment protocol in the lab for production of Sophorolipid and various derivatives have been successfully synthesized based on different fatty acid precursor molecules. Oleic acid Sophorolipid has been the most worked upon molecule in the lab and it has shown to possess many interesting properties. Metastasis arresting and cancer cell differentiation inducing capability of oleic acid sophorolipid (Ref) and its ability to form solid stable fluorescent meso-structures upon laser irradiation (ref) has recently been reported from my laboratory. Also there is work going on in the field of enzymology with special attention on Ntn hydrolase family of enzymes. There has been a keen focus on searching for Novel sources of the enzyme penicillin G acylase for its eventual application in resolution of racemic mixtures (Chiral resolution). Lastly there is also intense efforts towards the search for novel Quorum quenching enzymes and biomolecules that can successfully inhibit Quorum Sensing, the phenomenon of bacterial communication, and serve as potential future candidates for development of antibacterial therapeutics. In the light of such efforts my lab has been the first to report the ability of xylitol to act as a quorum sensing antagonist in gram negative marker strain Chromobacterium violaceum CV026.

Professional Experience

Selected Publications

  • Ruchira Mukherji, ; Nishant K Varshney, Priyabrata Panigrahi, C.G. Suresh And Asmita Prabhune , A new role for Penicillin Acylases: Quorum Quenching by Kluyvera citrophila Penicillin G Acylase. (, Enzyme Microbial Technology., 56, 1 - 7 (2014).
  • Ruchira Mukherji, † Anupam Samanta, ‡ Rajith Illathvalappil, ‡ Somak Chowdhury, § Asmita Prabhune, * And 5 and R. Nandini Devi*, Selective Imaging of Quorum Sensing Receptors in Bacteria Using Fluorescent Au Nanocluster Probes Surface Functionalized with Signal Molecules, ACS Appl. Mat., , (2014),
  • Sharath Balkrishna and Asmita Prabhune , Gamma-Glutamyl Transferases: A Structural, Mechanistic and Physiological Perspective", Frontiers in Biology., , 7984 - 7992 (2013).
  • Pooja Singh, Kasturi Joshi, Debanjan Guin And Asmita A. Prabhune, Chemically Conjugated Sophorolipids on CdTe QDs: A Biocompatible photoluminescence Nanocomposite for Theranostic Applications, Royal society of Chemistry, RSC Adv., 3, 22319 - -22325 (2013), DOI:10.1039/C3RA44535F.
  • Jayashree Kanrtak and Asmita Prabhune, Characterization of smallest active monomeric lipase from novel Rhizopus strain: Application in transesterification, (2012), Appl BiochemBiotechnol., 166:, 1769– - 1780 (2012).
  • Reetika Gupta and Asmita A. Prabhune*, Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and ?-linolenic acid, Biotechnol Letts., 34:, 701 - -707 (2012).
  • Pradeep Kumar Singh, Ruchira Mukherji, Kasturi Joshi- Navare, Abhik Banerjee, Rohan Gokhale, Asmita Prabhune* and Satishchandra Ogale, Fluorescent Sophorolipid Molecular Assembly and its Magnetic Nanoparticle loading: A Pulsed Laser Process. , Green Chem., 2013, 15 (4), –, 943 - 953 (0000).
  • Kasturi Joshi – Navare , Ruchira Mukherji and Asmita Prabhune, Crystalline xylitol production by a novel yeast- Pichia caribbica (HQ222812) and its application for quorum sensing inhibition in gram negative marker strain Chromobacterium violaceum CV026"), Applied Biochemistry and Biotechnology., March 2013, Volume 169, Issue 6, pp -, 1753 - 1763 (0000).

Research Interest

  • Enzymology AND Microbiology

Contact Details

Bacterial communication and bio-transformation lab
Division of Biochemical Sciences.
Phone 25902239/2228
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