B. Senthil kumar

B. Senthil kumar

Organic Chemistry Division

About Me

We are working in the areas of Medicinal chemistry and Total Synthesis of Natural products like small molecules for various biological applications.

We also working on development of New Synthetic Methodologies involving metal catalyzed C-H bond activation/oxidation and Synthesis of fluorescent based sensor probes for detection of toxic metal ions and its application in live cell bioimaging.

Professional Experience

  • 2020 - Current - Principal Scientist, CSIR-National Chemical Laboratory, Pune, India
  • 2015 - 2020 - Sr. Scientist, CSIR-National Chemical Laboratory, Pune, India
  • 2008 - 2015 - Scientist, CSIR-National Chemical Laboratory, Pune, India
  • 2005 - 2008 - Scientist B, CSIR-National Chemical Laboratory, Pune, India
  • 2004 - 2005-  Research Associate, Shasun Pharmaceutical R&D Ltd, Chennai, India                          
  • 2015  Ph.D - Organic Chemistry (Dr. C. V. Ramana, CSIR-NCL) Pune University, Pune, India
  • 2003 - 2004 - M.Phil.  Organic Chemistry, University of Madras, Chennai, India
  • 2000 - 2002 - M.Sc. Organic Chemistry, University of Madras, Chennai, India
  • 1996 - 1999 - B.Sc. Chemistry, Govt. Arts college (University of Madras), Dharmapuri, Tamil Nadu, India.

Selected Publications

  • Darole, R. S.; Choudhary, S. S.; Sharma, H.; Mali, B. P.; Gopu, B.; Vanka, K.; Senthilkumar And B, Brønsted acid and Ni(II)-catalyzed C–H oxidation/ rearrangement of cyclotriveratrylenes (CTVs) to cyclic and acyclic quinones as potential anticancer agents, Org. Biomol. Chem., 22, 1038 - 1046 (2024), DOI:10.1039/d3ob01428b.
  • Bagad, P. K.; Darole, R. S.; Krishna, G. R.; Senthilkumar And B, Highly Selective C-N and C-S Dual Functionalization of 1,3-Dicarbonyl Derivatives using TBHP as an Oxidant, J. Org. Chem., (Accepted), (2024), DOI:10.1021/acs.joc.4c00612.
  • Darole, R. S.; Bagad, P. K.; Gonnade, R. G.; Alagarasu, K.; Punekar, M.; Shukla, S.; Parashar, D.; Senthilkumar And B, Synthesis of novel rhodamine type Anthrone Spiro-lactam (ASL) analogues and evaluation of antiviral activity against dengue and chikungunya viruses, Eur. J. Med. Chem., 261, 115849 (2023), DOI:https://doi.org/10.1016/ j.ejmech.2023.115849.
  • Sudhakaran, S.; Shinde, G.P.; Aratikatla, K.E.; Kaulage, H.S.; Rana, P.; Parit, R.S.; Kavale, S.D.; Senthilkumar, B.; Punji And B, Nickel-Catalyzed Asymmetric Hydrogenation for the Synthesis of a Key Intermediate of Sitagliptin, Chem Asian J., 17, e2021012 (2022), DOI:10.1002/asia.202101208.
  • Mule, R.D.; Kumar, A.; Sancheti, P.S.; Senthilkumar, B.; Ku-mar, H.; Patil And N.T, BQ-AurIPr: A Redox-Active Anticancer Au(I) Complex that Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer, ChemRxiv., , (2022), DOI:10.26434/chemrxiv-2022-m3xxx.
  • 2. Mule, R.D.; Roy, R.; Mandal, K.; Chopra, D.; Dutta, T.; Sancheti, P.S.; Shinde, S.P.; Banerjee, S.; Koner, A.L.; Bhowal, R.; Senthilkumar, B.; Patil And N.T. , Interplay of Anion ??+ and ?+ ??+ Interactions in Novel Pyrido[2,1- Fluorescence Modulation and Applications in Live Cell Mitochondrial Imaging, Chem. Eur. J., , e202200632 (2022).
  • Mali, N.; Senthilkumar And B, Synthesis of Novel Biological Active 1,2,4,-Triazole Analogues, Chem. Proc., 4, 1 - 4 (2022), DOI:https://doi.org/10.3390/xxxxx.
  • Mule, R. D.; Kumar, A.; Sancheti, S. P.; Senthilkumar, B.; Kumar, H.; Patil And N. T, BQ-AurIPr: a redox-active anticancer Au(I) complex that induces immunogenic cell death, Chem. Sci., 13, 10779 - 10785 (2022), DOI:DOI: 10.1039/d2sc03756d.
  • Cao, W.; Senthilkumar, B.; Causin, V.; Swamy, V. P.; Wang, Y.; Saielli And G, Influence of the ion size on the stability of the smectic phase of ionic liquid crystals, Soft Matter., 16, 411 - 420 (2020).
  • Darole, R. S. Britto, C. D.; Mukherjee, A.; Gonnade, R. G.; Sekar, K.; Senthilkumar And B. , Anthrone-spirolactam and quinoline hybrid based sensor for selective detection of Fe3+ ions in water samples, Appl. Organomett. Chem., 34, e5867 (2020), DOI:10.1002/aoc.5867.
  • Aegurl, B.; Ram D. Mandle, R. D.; Shinde, P. G.; Parit, R. S.; Kamble, S. P.; Sudalai, A.; Senthilkumar And B. , Triethyl Phosphite/Benzoyl Peroxide Mediated Reductive Dealkylation of O-Benzoylhydroxylamines: A Cascade Synthesis of Secondary Amides, Eur. J. Org. Chem., , 4235 - 4238 (2020).
  • Banerjee, S.; Ambegave, S. B.; Mule, R. D.; Senthilkumar, B.; Patil And N. T, Gold-Catalyzed Alkynylative Meyer-Schuster Rearrangement, Org. Lett., 22(12), 4792 - 4796 (2020).
  • Banerjee, S.; Senthilkumar, B.; Patil And N. T, Gold-Catalyzed 1,2-Oxyalkynylation of N-Allenamides with Ethylnylbenziodoxolones, Org. Lett., 21, 1, 180 - 184 (2019), DOI:10.1021/acs.orglett.8b03651.
  • Senthilkumar, B.; Gonnade, R. G.; Ramana And C. V, Pd-catalyzed Benzylic C-H oxidation of cyclotriveratrylene – Product Diversity, Org. Biomol. Chem., 13, 2323 - 2329 (2014).
  • Ramana. C.V.; Senthilkumar B. , One-pot process for the conversion of aroyl chlorides to acyl thioureas, IN (3482/DEL/2012), PCT, WO2014087431A1, WO2014087431A8, US14/650,778., , (2013).
  • Rajakumar. P.; Senthilkumar. B.; Srinivasan. K. , Synthesis of Azobenzenophanes with a Large Molecular Cavity, Aust. J. Chem., 59 (1), 75 - 77 (2006).

Research Interest

  • Synthetic Organic Chemistry including development of methodologies

Contact Details

Dr. B. Senthil kumar

Principal Scientist &
Associate Professor (AcSIR)

Office: Room No. 206, Organic Chemistry Division
CSIR-National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India

Phone:+91 20 2590 2543. Fax +91 20 2590 2629
E-mail: b.senthilkumar@ncl.res.in