Chiranjit Chowdhury

Chiranjit Chowdhury

Biochemical Science Division

About Me

A trained Microbial Biochemist with interest in Bacterial Genetics, Gut Microbiome, Synthetic Biology, Antimicrobial Resistance and Chemotherapy and Protein Biochemistry.

Professional Experience

Selected Publications

  • Shinde YD And Chowdhury C, Potential utility of bacterial protein nanoreactor for sustainable in-situ biocatalysis in wide range of bioprocess conditions, Enzyme Microb Technol., 173, 110354 (2024), DOI:10.1016/j.enzmictec.2023.110354.
  • Das S, Chowdhury C, Kumar SP, Roy D, Gosavi SW And Sen R, Microbial production of N-acetyl-D-glucosamine (GlcNAc) for versatile applications: Biotechnological strategies for green process development, Carbohydr Res., 536, 109039 (2024), DOI:10.1016/j.carres.2024.109039.
  • Sutar AA, Dashpute RS, Shinde YD, Mukherjee S And Chowdhury C, A systemic review on fitness and survival of Salmonella in dynamic environment and conceivable way of its mitigation, Indian J Microbiol., , (2023), DOI:10.1007/s12088-023-01176-4.
  • Agarwal A, Kumar A, Garg P, Chakraborty A, Verma R, Sarwat M, Gupta A, Sasmal PK., Verma YK, Chowdhury C And Mukherjee M, Algal Biomass-Loaded Hydrogel Scaffolds as a Biomimetic Platform with Antibacterial and Wound Healing Activities, ACS Appl Polym Mater., 4, 5800 - 5812 (2022), DOI:10.1021/acsapm.2c00722.
  • Lundin AP, Stewart KI, Stewart AM, Herring TI, Chowdhury C And Bobik TA , Genetic characterization of a glycyl radical microcompartment used for 1,2-propanediol fermentation by uropathogenic Escherichia coli CFT073, J Bacteriol., 202, pii:e00017 - 20 (2020), DOI:10.1128/JB.00017-20.
  • Chowdhury C And Bobik TA , Engineering the PduT shell protein to modify the permeability of the 1,2-propanediol microcompartment of Salmonella, Microbiology., 165, 1355 - 1364 (2019), DOI:10.1099/mic.0.000872.
  • Herring TI, Harris TN, Chowdhury C, Mohanty S And Bobik TA , A bacterial microcompartment is used for choline fermentation by Escherichia coli 536, J Bacteriol., 200, pii: e0076 - 17 (2018), DOI:10.1128/JB.00764-17.
  • Lehman BP, Chowdhury C And Bobik TA , The N Terminus of the PduB Protein Binds the Protein Shell of the Pdu Microcompartment to Its Enzymatic Core, J Bacteriol., 199, pii: e0078 - 16 (2017), DOI:10.1128/JB.00785-16.
  • Chowdhury C, Chun S, Sawaya MR, Yeates TO And Bobik TA , The function of the PduJ microcompartment shell protein is determined by the genomic position of its encoding gene, Mol Microbiol., 101, 770 - 783 (2016), DOI:10.1111/mmi.13423.
  • Chowdhury C, Chun S, Pang A, Sawaya MR, Sinha S, Yeates TO And Bobik TA , Selective molecular transport through the protein shell of a bacterial microcompartment organelle, Proc Natl Acad Sci U S A., 112, 2990 - 2995 (2015), DOI:10.1073/pnas.1423672112.
  • Bansal A, Kar D, Rajagopal A. M., Mallick S, Dutta M, Pandey SD, Chowdhury C And Ghosh AS , A putative low-molecular mass (LMM) penicillin-binding protein (PBP) of Mycobacterium smegmatis exhibits prominent physiological characters of Carboxypeptidase and beta-lactamase, Microbiology., 161, 1081 - 1091 (2015), DOI:10.1099/mic.0.000074.
  • Chowdhury C, Sinha S, Chun S, Yeates TO And Bobik TA, Diverse Bacterial Microcompartment Organelles, Microbiol Mol Biol Rev., 78, 438 - 468 (2014), DOI:10.1128/MMBR.00009-14.
  • Chun S, Chowdhury C, Park J, Houk KN, Bobik TA And Yeates TO, Bacterial Microcompartments: Substrate Transport through Shell Pores, Prot Sci., 23, 162 - 163 (2014), DOI:10.1002/pro.2504.
  • Chowdhury C And Jagannadham MV , Virulence factors are released in association with outer membrane vesicles of Pseudomonas syringae pv. tomato T1 during normal growth, Biochim Biophys Acta., 1834, 231 - 239 (2013), DOI:10.1016/j.bbapap.2012.09.015.
  • Chowdhury C, Kar D, Dutta M, Kumar A And Ghosh AS , Moderate deacylation efficiency of DacD explains its ability to partially restore beta-lactam resistance in Escherichia coli PBP5 mutant, FEMS Microbiol Lett., 337, 73 - 80 (2012), DOI:10.1111/1574-6968.12009.
  • Jagannadham MV And Chowdhury C , Differential expression of membrane proteins helps Antarctic Pseudomonas syringae to acclimatize upon temperature variations, J Proteomics., 75, 2488 - 2499 (2012), DOI:10.1016/j.jprot.2012.02.033.
  • Sarkar SK, Dutta M*, Chowdhury C*, Kumar A And Ghosh AS (* Contributed equally) , PBP5, PBP6 and DacD play different roles in intrinsic ?-lactam resistance of Escherichia coli, Microbiology., 157, 2702 - 2707 (2011), DOI:10.1099/mic.0.046227-0.
  • Chowdhury C And Ghosh AS , Differences in active-site microarchitecture explain the dissimilar behaviors of PBP5 and 6 in Escherichia coli, J Mol Graph Model., 29, 650 - 656 (2011), DOI:10.1016/j.jmgm.2010.11.009.
  • Sarkar SK, Chowdhury C And Ghosh AS , Deletion of penicillin-binding protein 5 (PBP5) sensitises Escherichia coli cells to beta-lactam agents, Int J Antimicrob Agents., 35, 244 - 249 (2010), DOI:10.1016/j.ijantimicag.2009.11.004.
  • Chowdhury C, Nayak TR, Young KD And Ghosh AS , A weak DD-carboxypeptidase activity explains the inability of PBP 6 to substitute for PBP 5 in maintaining normal cell shape in Escherichia coli, FEMS Microbiol Lett., 303, 76 - 83 (2010), DOI:10.1111/j.1574-6968.2009.01863.x.
  • Ghosh AS, Chowdhury C And Nelson DE, Physiological functions of D-alanine carboxypeptidases in Escherichia coli, Trends Microbiol., 16, 309 - 317 (2008), DOI:10.1016/j.tim.2008.04.006.

Research Interest

  • Enzymology AND Microbiology
  • Structural Biology
  • Bio-chemical AND Biological Engineering
  • Human Diseases
  • Bioseparations
  • Biochemical Engineering
  • Molecular modelling and Bioinformatics
  • Protein Chemistry and Proteomics
  • Microbiology
  • Bacterial Genetics and Molecular Microbiology
  • Synthetic Biology
  • Metabolic Engineering
  • Recombinant DNA Technology
  • Protein Biochemistry and Structure-Function Relationship

Contact Details

Chiranjit Chowdhury, Ph. D.
Senior Scientist
1850, Biochemical Sciences Division,
CSIR-National Chemical Laboratory,
Dr. Homi Bhabha Road, Pashan
Pune, MH 411 008, India