Chetan Gadgil

Chemical Engineering & Process Development

About Me

We are interested in understanding biological systems through the formulation, simulation and analysis of mechanism-based mathematical models. We currently work on (i) transcription, translation and its regulation, including during the formation of memory; (ii) keratinocyte-melanocyte-immune system interactions including during melanogenesis; (iii) formulating models and frameworks for quantitative systems pharmacology studies; and (iv) the implications of stochasticity on biological system design and function

Professional Experience

  • Since Nov 2006: Scientist, National Chemical Laboratory, Pune, India
  • Since Nov 2008: Scientist, Institute of Genomics and Integrative Biology, New Delhi, India
  • 2005-2006: Mathematical Modeler (Investigator - grade), GlaxoSmithKline, King of Prussia, Pennsylvania, USA
  • 2004-2005: Mathematical Modeler (Scientist - grade), GlaxoSmithKline, Research Triangle Park, North Carolina, USA
  • 2001-2004: Postdoctoral Associate, School of Mathematics, University of Minnesota, USA

Selected Publications

  • For current record, please visit,, , (2019).
  • Bharat Ravi Iyengar, Beena Pillai, K.V. Venkatesh And Chetan J. Gadgil, Systematic comparison of the response properties of protein and RNA mediated gene regulatory motifs, Molecular BioSystems., 13, 1235 - 1245 (2017), DOI:10.1039/C6MB00808A.
  • Puntambekar S. S, Nyayanit D., Saxena P. And *Gadgil C. J, Identification of unintuitive features of sumoylation through mathematical modeling, J Biol Chem., , (2016), DOI:jbc.M115.676122.
  • Nyayanit D. And *Gadgil C. J, Mathematical modelling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for mRNA, RNA., 21(3), 307 - 319 (2015).
  • Natarajan V.T., Ganju P., Singh A., Vijayan V., Kirty K., Yadav S., Puntambekar S., Bajaj S., Dani P.P., Kar H.K., Gadgil C.J., Natarajan K., Rani R. And *Gokhale R.S, IFN-\gamma signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation, PNAS., 111(6), 2301 - 2306 (2014).
  • Gokhale S And *Gadgil C.J. , A mathematical model identifies conditions for 'unexpected' increase in target protein levels due to miRNA regulation, Mol. BioSyst., 8 (3), 760 - 765 (2012).
  • Gadgil C.J, Size-independent differences between the mean of discrete stochastic systems and the corresponding continuous deterministic systems, Bulletin of Mathematical Biology., 71, 1599 - 1611 (2009).

Research Interest

  • Bio-chemical AND Biological Engineering
  • Mathematical Modeling & Optimization
  • Theory AND Computational Science
  • Biochemical Engineering
  • Mathematical & computational modeling
  • Bioinformatics
  • Kinetics analysis of Chemical Reactions
  • Chemical Reaction Engineering

Contact Details