Dhanasekaran Shanmugam

Dhanasekaran Shanmugam

Biochemical Science Division

About Me

Research work in my laboratory is focused on studying cellular metabolism in apicomplexan parasites such as P. falciparum and T. gondii. Carbon and energy metabolic pathways in these parasites contain some unique features and in many instances are divergent or different from host species such as humans. Our interest is to understand various aspects of metabolic adaptation evolved by these parasites to sustain a parasitic life style and exploit unique and essential aspects of these metabolic features for identifying novel chemical inhibitors as leads for drug discovery. The approaches employed by our group will include a combination of genomic, biochemical, genetic and metabolomic techniques.

Professional Experience

  • 2012 - Current: Scientist, National Chemical Laboratory, Pune, India
  • 2004-2011: Post Doctoral Research Fellow (with Prof. Dr. David S. Roos, University of Pennsylvania, Philadelphia, USA.
  • 1997-2004 Ph.D Student (with Prof. G. Padmanaban, Indian Institute of Science, Bangalore, India)

Selected Publications

  • Reid J. A, Vermont J. S, Cotton A. J, Harris D, Hill-Cawthorne A. G And Ko, Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy, PLOS Pathogens., 8(3):e1002567, (2012).
  • Magarinos MP, Carmona SJ, Crowther GJ, Ralph SA, Roos DS, Shanmugam D And Van Voorhis WC, Aguero F. TDR Targets: a chemogenomics resource for neglected diseases, Nuc. Acid Res. 40:D1118-27. ., , (2012).
  • Shanmugam D, Ralph SA, Carmona SJ, Crowther GJ, Roos DS And Ferna, Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets. (2012). In Press ? ? titled Chemo- and Immuno-therapeutic advances for treatment and control of helminthic infections. , Wiley Book Series (Vol 4) on ?Drug Discovery in Infectious Diseases., , (2012).

Research Interest

  • Biomolecular Chemistry
  • Chemical Biology
  • Theory AND Computational Science
  • Human Diseases
  • Proteomics and Metabolomicsy
  • Structure Biology

Contact Details

Dr. Dhanasekaran Shanmugam

Office: 1908, Biochemical Sciences Division
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone  +91 20 2590 2719
Fax +91 20 2590 2648
E-mail d.shanmugam@ncl.res.in