D. Srinivasa Reddy

D. Srinivasa Reddy

Organic Chemistry Division

About Me

Our group research interests are broadly in total synthesis of biologically active compounds and medicinal chemistry. Current projects include the total synthesis of bioactive natural products such as antiinflammatory agents, antibacterial agents, antimalarial compounds and anti-cancer agents. Targets are chosen for their interesting biological activity and moderate complexity, which drives our creative solutions to their synthesis. Our ability to achieve an efficient synthesis enables us to access sufficient quantities of target molecule for biological profiling and ready access to different analogs that may prove to be more selective and efficacious as a drug-like molecule. We have plans to divert our total synthesis projects into medicinal chemistry projects by simplifying the complex structures. In medicinal chemistry front, our main interest is to use "silicon-switch approach" to discover novel drugs or drug-like molecules with improved pharmacokintetic (PK) and pharmacodynamic (PD) properties.

Professional Experience

  • 2010- Current- Scientist, National Chemical Laboratory, Pune, India
  • 2007-2010 Group Leader / Section Head, Discovery Chemistry, Advinus Therapeutics Pvt. Ltd, Pune, India
  • 2003-2007 Principal Scientist / Research Investigator, Discovery Chemistry, Dr. Reddys Laboratories Ltd., Hyderabad, India
  • 2001-2003 Post Doctoral Research Fellow (with Prof. Prof. Jeffrey Aub, Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA)
  • 2000-2001 Post Doctoral Research Fellow (with Prof. Prof. Sergey A. Kozmin, Department of Chemistry, University of Chicago, Chicago, IL, USA)
  • 1994-2000 Ph.D Student (with Prof. Goverdhan Mehta, University of Hyderabad, Hyderabad / Indian Institute of Science, Bangalore, India)

Selected Publications

  • Kalai Mangai Muthukumarasamy, Kishor L. Handore, Dipti N. Kakade, Madhuri V. Shinde, Shashi Ranjan, Naveen Kumar, Seema Sehrawat, Chetana Sachidanandan And D. Srinivasa Reddy, Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays, Organic & Biomolecular Chemistry., 14, 1569 - 1578 (2016), DOI:10.1039/C5OB01594D.
  • B. Seetharamsingh, Pankaj V. Khairnar And D. Srinivasa Reddy, First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674, J. Org. Chem., 81, 290 - 296 (2016), DOI:10.1021/acs.joc.5b02318.
  • Gorakhnath R Jachak, Remya Ramesh, Duhita G Sant, Shweta U Jorwekar, Manjusha R Jadhav, Santosh G Tupe, Mukund V Deshpande And D. Srinivasa Reddy, Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evalution, ACS Med Chem Letters., , 0000 - 0000 (2015), DOI:10.1021/acsmedchemlett.5b00245.
  • B. Seetharamsingh, P. R. Rajamohanan And D. Srinivasa Reddy, Total Synthesis and Structural Revision of Mycalol, an Anticancer Natural Product from the Marine Source, Organic letters., , 1652 - 1655 (2015), DOI:10.1021/acs.orglett.5b00345.
  • K. Kashinath, Santu Dhara And D. Srinivasa Reddy, Breaking and Making of Olefins Simultaneously Using Ozonolysis: Application to the Synthesis of Useful Building Blocks and Macrocyclic Core of Solomonamides, Organic letters., 17, 2090 - 2093 (2015), DOI:10.1021/acs.orglett.5b00637.
  • N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy, Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor, Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048.
    Early view
  • B. Seetharamsingh, Remya Ramesh, Santoshkumar S. Dange, Pankaj V. Khairnar, Smita Singhal, Dilip Upadhyay, Sridhar Veeraraghavan, Srikant Viswanadha, Swaroop Vakkalanka And D. Srinivasa Reddy, Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure, ACS Med. Chem. Lett., , 0000 (2015), DOI:10.1021/acsmedchemlett.5b00213.
    Dedicated to Professor Sourav Pal, Indian Institute of Technology, Bombay and former Director, CSIR-NCL, Pune on the occasion of his 60th birthday.
  • Kishor L. Handore, Prakash D. Jadhav, Bibhabasu Hazra, Anirban Basu And D. Srinivasa Reddy, Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues, ACS Med Chem Letters., 6, 1117 - 1121 (2015), DOI:10.1021/acsmedchemlett.5b00241.
  • Remya Ramesh And D. Srinivasa Reddy, Zinc mediated allylations of chlorosilanes promoted by ultrasound: Synthesis of novel constrained sila amino acids, Organic & Biomolecular Chemistry., 12, 4093 (2014), DOI:10.1039/C4OB00294F.
  • Kishor L. Handore And D. Srinivasa Reddy, Total Synthesis of (±)-Nardoaristolone B and Its Analogues, Organic letters., 16, 4252 (2014).
  • N. Vasudevan, K. Kashinath And D. Srinivasa Reddy, Total Synthesis of Deoxy-solomonamide B by Mimicking Biogenesis, Organic letters., 16, 6148 - 6151 (2014), DOI:10.1021/ol503011g.
  • Rahul D. Shingare, R. Velayudham, Jalindar R. Gawade And D. Srinivasa Reddy, First total synthesis of Hunanamycin A, Organic letters., 15, 4556 - 4559 (2013).
  • Kishor L. Handore, B. Seetharamsingh And D. Srinivasa Reddy, Ready access to functionally emebellished cis- Hydrindanes and cis- Decalins: Protecting group free total syntheses of (±)-Nootkatone and (±)-Noreremophilane, J. Org. Chem., 78, 8149 - 8154 (2013).
  • Remya Ramesh, Pandrangi Siva Swaroop, Rajesh. G. Gonnade, Choppari Thirupathi, Rebeccah A. Waterworth, Jocelyn G. Millar And D. Srinivasa Reddy, Synthesis and determination of absolute configurations and biological activities of the enantiomers of the longtailed mealybug pheromone, J. Org. Chem., 78, 6281 - 6284 (2013).
  • Kishor L. Handore And D. Srinivasa Reddy, A diverted total synthesis of potent cell adhesion inhibitor Peribysin E analogues, Organic letters., 15, 1894 - 1897 (2013).
  • Satish Chandra Philkhana, B. Seetharam Singh, Yuvraj B. Dangat, Kumar Vanka And D. Srinivasa Reddy, Synthesis of Palmyrolide A and its cis-isomer and mechanistic insight into trans-cis isomerisation of the enamide macrocycle, Chem. Commun., 49, 3342 - 3344 (2013).

Research Interest

  • Total Synthesis
  • NATURAL Products
  • Medicinal Chemistry
  • Synthetic Organic Chemistry including development of methodologies
  • Organic Chemistry

Contact Details

Dr. D. Srinivasa Reddy

Senior Scientist
KG Lab, First Floor
Organic Chemistry Division
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone  +91 20 2590 2445
Fax +91 20 2590 2624
E-mail ds.reddy@ncl.res.in