D. Srinivasa Reddy

D. Srinivasa Reddy

Organic Chemistry Division

About Me

Our group research interests are broadly in total synthesis of biologically active compounds and medicinal chemistry. Current projects include the total synthesis of bioactive natural products such as antiinflammatory agents, antibacterial agents, antimalarial compounds and anti-cancer agents. Targets are chosen for their interesting biological activity and moderate complexity, which drives our creative solutions to their synthesis. Our ability to achieve an efficient synthesis enables us to access sufficient quantities of target molecule for biological profiling and ready access to different analogs that may prove to be more selective and efficacious as a drug-like molecule. We have plans to divert our total synthesis projects into medicinal chemistry projects by simplifying the complex structures. In medicinal chemistry front, our main interest is to use "silicon-switch approach" to discover novel drugs or drug-like molecules with improved pharmacokintetic (PK) and pharmacodynamic (PD) properties.

Professional Experience

  • 2010- Current- Scientist, National Chemical Laboratory, Pune, India
  • 2007-2010 Group Leader / Section Head, Discovery Chemistry, Advinus Therapeutics Pvt. Ltd, Pune, India
  • 2003-2007 Principal Scientist / Research Investigator, Discovery Chemistry, Dr. Reddys Laboratories Ltd., Hyderabad, India
  • 2001-2003 Post Doctoral Research Fellow (with Prof. Prof. Jeffrey Aub, Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA)
  • 2000-2001 Post Doctoral Research Fellow (with Prof. Prof. Sergey A. Kozmin, Department of Chemistry, University of Chicago, Chicago, IL, USA)
  • 1994-2000 Ph.D Student (with Prof. Goverdhan Mehta, University of Hyderabad, Hyderabad / Indian Institute of Science, Bangalore, India)

Selected Publications

  • Paresh R. Athawale, Vishal Zade, Gamidi Rama Krishna And D. Srinivasa Reddy*, Tuning of ?-Silyl Carbocation Reactivity into Enone Transposition: Application to the Synthesis of Peribysin D, E-Volkendousin, and E-Guggulsterone, Org. Lett., 23, 6642 - 6647 (2021), DOI:10.1021/acs.orglett.1c02173.

Research Interest

  • Total Synthesis
  • NATURAL Products
  • Medicinal Chemistry
  • Synthetic Organic Chemistry including development of methodologies
  • Organic Chemistry

Contact Details

Dr. D. Srinivasa Reddy

Senior Scientist
KG Lab, First Floor
Organic Chemistry Division
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone  +91 20 2590 2445
Fax +91 20 2590 2624
E-mail ds.reddy@ncl.res.in