Kiran A. Kulkarni

Kiran A. Kulkarni

Biochemical Science Division

About Me


Professional Experience

  • 2023-Present Senior Principal Scientist
  • 2018-2023 Principal Scientist
  • 2013-2018 Senior Scientist
  • 2009-2013 Postdoctoral Fellow Institute of Cancer Research, London
  • 2007-2009 Application Scientist,  Jawaharlal Nehru Centre For Advanced Scientific Research Bengaluru, Karnataka


Selected Publications

  • Aishwarya Omble And Kiran Kulkarni*, GPCRs that Rhoar the Guanine nucleotide exchange factors, Small GTPases., 13, 84 - 99 (2022), DOI:10.1080/21541248.2021.1896963.
  • Kalshetti RG, Rajput R, Motiwala Z, Srinivasa Reddy D*, Kulkarni KA* And Ramana CV* (*Corrosponding authors), Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins, Bioorg Med Chem Lett., 77, 129722 (2022), DOI:10.1016/j.bmcl.2022.129022.
  • Amit Kumawat, Suman Chakrabarty* And Kiran Kulkarni*, Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions, Sci. Reports., 7:45829, 1 - 11 (2017), DOI:10.1038/srep45829.
  • Ioannis Manolaridis*, Kiran Kulkarni*, Roger B. Dodd, Satoshi Ogasawara, Ziguo Zhang, Ganka Bienva, Nicola O’ Reilly, Sarah J. Hanrahan, Andrew J. Thompson, Nora Cronin And So Iwata and David Barford. (* Equal first author), Mechanism of prenylated CAAX protein processing by the integral membrane protease Rce1, Nature., 504, 301 - 305 (2013), DOI:10.1038/nature12754.
  • William C.H. Chao*, Kiran Kulkarni*, Ziguo Zhang, Eric H. Kong And David Barford (* Equal first author), Structure of the mitotic checkpoint complex, Nature., 484, 208 - 213 (2012), DOI:10.1038/nature10896.
  • Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger B. Dodd, Corine Mas-Droux And David Barford , Crystal structure of ICMT reveals the mechanism of CAAX motif postprenyl modification by an integral membrane carboxyl methyltransferase, Mol. Cell., 44, 997 - 1004 (2011), DOI:10.1016/j.molcel.2011.10.020.
  • Kulkarni K, Yang J, Zhang Z And Barford D. , Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors, J. Biol. Chem., 286, 25341 - 25351 (2011), DOI:10.1074/jbc.M111.236455.
  • Kulkarni KA, Katiyar S, Surolia A, Vijayan M And Suguna K, Crystal structure of basic winged bean lectin complexed with alpha Gal containing disaccharide with different linkages, Acta Crystallogr D Biol Crystallogr., D64, 730 - 737 (2008), DOI:10.1107/S0907444908011323.

Research Interest

  • Bio-chemical AND Biological Engineering
  • Chemical Biology
  • Human Diseases
  • Structure Biology
  • Biochemical Engineering
  • Bioinformatics & Computational Chemistry
  • Drug Design and Virtual Screening
  • Biomolecular Crystallography and conformational analysis
  • Biophysical Science

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