Moneesha Fernandes

Moneesha Fernandes

Organic Chemistry Division

About Me


Professional Experience


Selected Publications

  • Manisha Aher, Vaijayanti A. Kumar And Moneesha Fernandes , Implications of Natural 3'-5'- Linkages in the Loop Region of Isomeric 2'-5'-Linked Thrombin-Binding Aptamer, ChemistrySelect., 9, e202304254 (2024), DOI:10.1002/slct.202304254.
  • Atish A. Wagh, Vaijayanti A. Kumar, Sapna Ravindranathan And Moneesha Fernandes, Unlike RNA-TBA (rTBA), iso-rTBA, the 2'–5'-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA, Chem. Commun., 59, 1461 - 1464 (2023), DOI:10.1039/d2cc05718b.
  • S. Ghosh, K. B. Cotta, A. A. Hande, M. Fernandes And S. Mehra, PNA-mediated efflux inhibition as a therapeutic strategy towards overcoming drug resistance in Mycobacterium smegmatis, Microbial Pathogenesis., 151, 104737 (2021).
  • Wagh A. A, Ghalawat M. And Fernandes M, Replacement of Loop Residues in TBA by an Abasic Ethylene Glycol Spacer: Effect on Stability, Structure and Function, ChemistrySelect., 6, 10648 - 10650 (2021), DOI:https://doi.org/10.1002/slct.202102269.
  • M. Varada, M. Aher, N. Erande, V. A. Kumar And M. Fernandes, Methoxymethyl Threofuranosyl Thymidine (4?-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance, ACS Omega., 5, 498 - 506 (2020).
  • M. N. Aher, N. D. Erande, V. A. Kumar, M. Fernandes And R. G. Gonnade, Influence of fluorine substitution on the molecular conformation of 3'-deoxy-3'-fluoro-5-methyluridine, Acta Crystallogr. C. Struct. Chem., 76, 346 - 352 (2020), DOI:https://doi.org/10.1107/S2053229620003083.
  • A. K. Yadav, H. Chilukuri, L. R. Kumari, M. Karthikeyan And M. Fernandes, p-Nitrophenylcarbonates: A New Class of Compounds for Chemodosimetric Colorimetric Fluoride Anion Sensing Detectable by the Naked Eye, ChemistrySelect., 4, 1830 - 1833 (2019).
  • A. A. Wagh And M. Fernandes, 2’-5’-Isomerically Linked Thrombin-Binding Aptamer (isoTBA) Forms a Stable Unimolecular Parallel G-Quadruplex in the Presence of Sr2+ Ions, ChemistrySelect., 4, 10668 - 10673 (2019).
  • Govind S. Bhosle, Shalmali Kharche, Santosh Kumar, Durba Sengupta, Souvik Maiti And Moneesha Fernandes, Superior HIV-1 TAR Binders with Conformationally Constrained R52 Arginine Mimics in the Tat(48-57) Peptide, ChemMedChem., 13, 220 - 226 (2018).
  • Nidhi S. Saikhedkar, Rakesh S. Joshi, Ashiwini S. Bhoite, Radhika Mohandasan, Amit Kumar Yadav, Moneesha Fernandes, Kiran A. Kulkarni And Ashok P. Giri, Tripeptides derived from reactive centre loop of potato type II protease inhibitors preferentially inhibit midgut proteases of Helicoverpa armigera, Insect Biochem. Mol. Biol., 95, 17 - 25 (2018).
  • Ragini Awachat, Atish A. Wagh, Manisha Aher, Moneesha Fernandes And Vaijayanti A. Kumar, Favorable 2'-substitution in the loop region of a thrombin-binding DNA aptamer, Bioorg. Med. Chem. Lett., 28, 1765 - 1768 (2018).
  • Govind S. Bhosle, Laxman Nawale, Amar M. Yeware, Dhiman Sarkar And Moneesha Fernandes, Antibacterial and anti-TB tat-peptidomimetics with improved efficacy and half-life, Eur. J. Med. Chem., 152, 358 - 369 (2018).
  • Govind S. Bhosle And Moneesha Fernandes, (R-X-R)-Motif Peptides Containing Conformationlly Constrained Cyclohexane-Derived Spacers: Effect on Cellular Uptake, ChemMedChem., 12, 1743 - 1747 (2017).
  • Amit Kumar Yadav, Namit Dey, Sabyasachi Chattopadhyay, Munia Ganguli And Moneesha Fernandes, Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters, Org. Biomol.Chem., 15, 9579 - 9584 (2017).
  • Manika Vij, †, ‡, § Poornemaa Natarajan, †, § Amit K. Yadav, ? Kiran M. Patil, ? Tanuja Pandey, † Nidhi Gupta, ? Deenan Santhiya, ? Vaijayanti A. Kumar, ? Moneesha Fernandes, *, ? and Munia Ganguli*, † And ‡, Efficient Cellular Entry of (r-x-r)-Type Carbamate?Plasmid DNA Complexes and Its Implication for Noninvasive Topical DNA Delivery to Skin, Molecular Pharmaceutics., 13, 1779 - 1790 (2016), DOI:10.1021/acs.molpharmaceut.5b00915.
  • A13. Seema Bagmare, Vedavati G. Puranik, Moneesha Fernandes And Vaijayanti A. Kumar, 4'-Epi-DNA: A DNA Mimic Containing 4'-hydroxymethyl-?-l-Xylo-Thymidine with Compact Backbone like RNA, Nucleosides Nucleotides Nucleic Acids., 35, 445 - 458 (2016).
  • Manisha N. Aher, Namrata D. Erande, Moneesha Fernandes And Vaijayanti A. Kumar, Unimolecular antiparallel G-quadruplex folding topology of 2’–5’-isoTBA sequences remains unaltered by loop composition, Org. Biomol. Chem., 13, 11696 - 11703 (2015), DOI:10.1039/c5ob01923k.
  • Harsha Chilukuri, Yogesh M. Kolekar, Govind S. Bhosle, Rashmi K. Godbole, Rubina S. Kazi, Mahesh J. Kulkarni* And Moneesha Fernandes*, N-(3-Aminoalkyl)proline derivatives with potent antigycation activity, RSC Adv., 5, 77332 - 77340 (2015), DOI:10.1039/c5ra12148e.
  • Kiran M. Patil, Rangeetha J. Naik, Manika Vij, Amit K. Yadav, Vaijayanti A. Kumar, Munia Ganguli* And Moneesha Fernandes*, Second generation, arginine-rich (R–X'–R)4-type cell-penetrating alpha–omega–alpha-peptides with constrained, chiral omega-amino acids (X') for enhanced cargo delivery into cells, Bioorg. Med. Chem. Lett., 24, 4198 - 4202 (2014), DOI:10.1016/j.bmcl.2014.07.040.
  • Anita D. Gunjal, Moneesha Fernandes, Namrata Erande, P. R. Rajamohanan And Vaijayanti A. Kumar, Functional isoDNA aptamers: modified thrombin binding aptamers with a 2'-5'-linked sugarphosphate backbone (isoTBA), Chem. Commun., 50, 605 - 607 (2014), DOI:10.1039/c3cc47569g.
  • Namrata Erande, Anita D. Gunjal, Moneesha Fernandes, Rajesh Gonnade And Vaijayanti A. Kumar, Synthesis and structural studies of S-type/N-type locked/ frozen nucleoside analogues and their incorporation in RNA-selective, nuclease resistant 2’–5’ linked oligonucleotides, Org. Biomol. Chem., 11, 746 - 757 (2013), DOI:10.1039/c2ob26762d.
  • Kiran M. Patil, Rangeetha J. Naik, Rajpal, Moneesha Fernandes, Munia Ganguli And Vaijayanti A. Kumar, Highly Efficient (R-X-R)-Type Carbamates as Molecular Transporters for Cellular Delivery, J. Am. Chem. Soc., 134, 7196 - 7199 (2012), DOI:10.1021/ja210026m.
  • Venubabu Kotikam, Moneesha Fernandes And Vaijayanti Anil Kumar, Comparing the interactions of DNA, polyamide (PNA) and polycarbamate nucleic acid (PCNA) oligomers with graphene oxide (GO), Phys. Chem. Chem. Phys., 14, 15003 - 15006 (2012), DOI:10.1039/c2cp42770b.

Research Interest

  • Biomolecular Chemistry
  • Chemical Biology
  • Organic Chemistry

Contact Details

Room# 114, Lab # 109, Org. Chem. Div., NCL Main Building, ground floor.