M. Muthukrishnan

M. Muthukrishnan

Organic Chemistry Division

About Me

We work in the field of organic synthesis with our main focus on asymmetric synthesis of biologically significant compounds employing various strategies

We are also interested in developing a strategies in the design and synthesis of novel natural-product like small molecules for various biological applications

Professional Experience

since 2001  | Scientist, National Chemical Laboratory, Pune, India


2003-2004 | Post Doctoral Fellow (Kyushu Institute of Technology, Kitakyushu, Japan)

2003          | Ph.D Organic Chemistry (TBGRI, Trivandrum) 

Selected Publications

  • Vijay Vara, Kishor R. Thete, Akram A. Khan And and M. Muthukrishnan*, Radical-promoted cyclization of 3-allyl-2-arylquinazolinones mediated by silver(I) salts to access SCF3/SCN-enriched dihydroisoquinolino[1,2-b]quinazolinones, Organic & Biomolecular Chemistry., 24, 1263 - 1267 (2026), DOI:10.1039/d5ob01755f.
  • Kishor R. Thete, Vijay Vara And Raj Y. Patel and M. Muthukrishnan*, Copper-catalyzed radical 1,2-oxysulfoximination of ?,?-unsaturated oximes for the synthesis of sulfoximine-substituted isoxazolines, Organic & Biomolecular Chemistry., 24, 2910 - 2915 (2026), DOI:10.1039/d6ob00244g.
  • Ravi A. Shinde, Sachin Shirsath And and M. Muthukrishnan*, Iron Mediated Oxidative Ring Opening-Homocoupling of Cyclopropanols: Facile Access to 1,6-Diketones, ChemistrySelect., ChemistrySelect 2025, 10, e202501745, (2025), DOI:doi.org/10.1002/slct.202501745.
  • Kishor R. Thete, Vijay Vara, Akram A. Khan And and M. Muthukrishnan*, Phosphine-Catalyzed Nucleophilic Ring Opening of Cyclopropenones with Sulfoximines to Access N??,?-Unsaturated Acyl Sulfoximines, The Journal of Organic Chemistry., 90, 10643 - 10653 (2025), DOI:https://doi.org/10.1021/acs.joc.5c00883.
  • Vijay Vara, Kishor R. Thete, Sera Deepu Panikar, Akram A. Khan And and M. Muthukrishnan*, Ag(I)-Catalyzed Heterocyclization/[3 + 2] Cycloaddition of ?-Alkynylenones with ??Enaminones: Tandem Access to Highly Substituted Cyclopenta[c]furans, The Journal of Organic Chemistry., 90, 12466 - 12479 (2025), DOI:https://doi.org/10.1021/acs.joc.5c01707.
  • Devidas A. More, P. R. Gayathri, Kishor R. Thete And and M. Muthukrishnan*, Visible-Light Mediated C-3 Amination of Quinoxalin 2(1H)-ones via Electron Donor-Acceptor Complexation, Asian Journal of Organic Chemistry., Asian J. Org. Chem. 2024, 13, e202400150, (2024), DOI:doi.org/10.1002/ajoc.202400150.
  • Vijay Vara, Kishor R. Thete, Ganesh S. Ghotekar And Prof.?Dr. M. Muthukrishnan*, Manganese-Mediated Cascade Radical Oxidative Cyclization/1,6-Conjugate Addition of Unsaturated Oximes with p-Quinone Methides: Facile Access to ?,?-Diarylmethine Substituted Isoxazolines, Chemistry an Asian Journal., Chem Asian J. 2025, 20, e202401079, (2024), DOI:https://doi.org/10.1002/asia.202401079.
  • Mohammad Mujahid, Vijay Vara, Usman Arshad, Rama Krishna Gamidi And and M. Muthukrishnan*, Cu-Catalyzed Multicomponent Reaction of Arylhydrazines with ?-Ketoesters and TBN: One-Pot Access to N2-Aryl 1,2,3-Triazole-1-Oxides, The Journal of Organic Chemistry., J.Org.Chem.2024,89,16990?16998, (2024), DOI:https://doi.org/10.1021/acs.joc.4c00298.
  • Ravi A. Shinde, Ganesh S. Ghotekar, Sagar S. Saswade And M. Muthukrishnan*, Palladium-Catalyzed Oxidative Cyclization of ?-Allenols in the Presence of TBN: Access to 3(2H)-Furanones, The Journal of Organic Chemistry., J. Org. Chem. 2023, 88, 4112-4122, (2023), DOI:https://doi.org/10.1021/acs.joc.2c02457.
  • Ganesh S. Ghotekar, Sachin R. Shirsath And Aslam C. Shaikh and M. Muthukrishnan*, 1,6-Conjugate addition initiated formal [4+2] annulation of p-quinone methides with sulfonyl allenols: a unique access to spiro[5.5]undeca-1,4-dien-3-one scaffolds, Chemical Communications., 56, 5022 - 5025 (2020), DOI:https://doi.org/10.1039/D0CC01005G.
  • Sachin R. Shirsath, Ganesh S. Ghotekar, Vir Bahadur, Rajesh G. Gonnade And M. Muthukrishnan*, Silver-Catalyzed Cascade Cyclization/1,6-Conjugate Addition of Homopropargyl Sulfonamides to p-Quinone Methides: An Approach to Diverse 3-Diarylmethine Substituted Dihydropyrroles, The Journal of Organic Chemistry., 85, 15038 - 15050 (2020), DOI:https://doi.org/10.1021/acs.joc.0c01922.
  • Ganesh S. Ghotekar, Mohammad Mujahid And M. Muthukrishnan*, Total Synthesis of Marine Natural Products Serinolamide A and Columbamide D, ACS Omega., 4, 1322 - 1328 (2019), DOI:10.1021/acsomega.8b03417.
  • N.Viswanadh, Ganesh S. Ghotekar, Mahesh B. Thoke, R.Velayudham, Aslam C. Shaikh, M. Karthikeyanbc And M. Muthukrishnan*, Transition Metal Free Regio-selective C-H Hydroxylation of Chromanones towards the Synthesis of Hydroxyl-Chromanones using PhI(OAc)2 as Oxidant, Chemical Communications., , (2018), DOI:10.1039/C7CC08588E.
  • Sachin R. Shirsath, Ganesh H. Shinde, Aslam C. Shaikh And M. Muthukrishnan* , Accessing alpha Arylated Nitriles via BF3·OEt2 Catalyzed Cyanation of para-Quinone Methides Using tert-Butyl Isocyanide as a Cyanide Source, The Journal of Organic Chemistry., 83, 12305 - 12314 (2018), DOI:10.1021/acs.joc.8b01926.

Research Interest

  • Innovative methods for the production of organic chemicals

Contact Details

Dr. M. Muthukrishnan

Scientist

Office: 206, Organic Chemistry Division,
Main-Building, CSIR-National Chemical Laboratory,
Dr. Homi Bhabha Road, Pashan,
Pune-411008, India.


Phone : +91 20 2590 2284
Fax     : +91 20 2590 2629
E-mail  : m.muthukrishnan@ncl.res.in