M. Muthukrishnan

M. Muthukrishnan

Organic Chemistry Division

About Me

We work in the field of organic synthesis with our main focus on asymmetric synthesis of biologically significant compounds employing various strategies

We are also interested in developing a strategies in the design and synthesis of novel natural-product like small molecules for various biological applications

Professional Experience

  • 2001- Current- Scientist, National Chemical Laboratory, Pune, India
  • 2003-2004 Post Doctoral Fellow (Kyushu Institute of Technology, Kitakyushu, Japan)
  • 2003 Ph.D Organic Chemistry (TBGRI, Trivandrum) 

Selected Publications

  • Ganesh S. Ghotekar, Sachin R. Shirsath And Aslam C. Shaikh and M. Muthukrishnan*, 1,6-Conjugate addition initiated formal [4+2] annulation of p-quinone methides with sulfonyl allenols: a unique access to spiro[5.5]undeca-1,4-dien-3-one scaffolds, Chemical Communications., 56, 5022 - 5025 (2020), DOI:https://doi.org/10.1039/D0CC01005G.
  • Sachin R. Shirsath, Ganesh S. Ghotekar, Vir Bahadur, Rajesh G. Gonnade And M. Muthukrishnan*, Silver-Catalyzed Cascade Cyclization/1,6-Conjugate Addition of Homopropargyl Sulfonamides to p-Quinone Methides: An Approach to Diverse 3-Diarylmethine Substituted Dihydropyrroles, The Journal of Organic Chemistry., 85, 15038 - 15050 (2020), DOI:https://doi.org/10.1021/acs.joc.0c01922.
  • Ganesh S. Ghotekar, Mohammad Mujahid And M. Muthukrishnan*, Total Synthesis of Marine Natural Products Serinolamide A and Columbamide D, ACS Omega., 4, 1322 - 1328 (2019), DOI:10.1021/acsomega.8b03417.
  • Ganesh S. Ghotekar, Aslam C. Shaikh And M. Muthukrishnan*, Transition-Metal-Free Benzannulation of Tricarbonyl Derivatives with Arynes: Access to 1,3-Dinaphthol Precursors for the Synthesis of Rhodamine Dye Analogues, The Journal of Organic Chemistry., 84, 2269 - 2276 (2019), DOI:10.1021/acs.joc.8b02560.
  • Devidas A. More, Ganesh H. Shinde, Aslam C. Shaikh And M. Muthukrishnan*, Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams†, RSC Advances., 9, 30277 - 30291 (2019), DOI:10.1039/C9RA06212B.
  • Ganesh S. Ghotekar, Devidas A. More, Viswanadh Nalla And M. Muthukrishnan*, A new enantioselective synthesis of antiobesity drug lorcaserin, New Journal of Chemistry., 43, 16876 - 16880 (2019), DOI:10.1039/C9NJ04234B.
  • N.Viswanadh, Ganesh S. Ghotekar, Mahesh B. Thoke, R.Velayudham, Aslam C. Shaikh, M. Karthikeyanbc And M. Muthukrishnan*, Transition Metal Free Regio-selective C-H Hydroxylation of Chromanones towards the Synthesis of Hydroxyl-Chromanones using PhI(OAc)2 as Oxidant, Chemical Communications., , (2018), DOI:10.1039/C7CC08588E.
  • Sachin R. Shirsath, Ganesh H. Shinde, Aslam C. Shaikh And M. Muthukrishnan* , Accessing alpha Arylated Nitriles via BF3·OEt2 Catalyzed Cyanation of para-Quinone Methides Using tert-Butyl Isocyanide as a Cyanide Source, The Journal of Organic Chemistry., 83, 12305 - 12314 (2018), DOI:10.1021/acs.joc.8b01926.
  • M. Mujahid, R. G. Gonnade, P. Yogeeswari, D. Sriram And M. Muthukrishnan, Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates, Bioorg. Med. Chem. Lett., 23, 1416 (2013).
  • M. Mujahid, P. Mujumdar, M. Sasikumar And M. Muthukrishnan, An alternate synthesis of enantiomerically pure Levetiracetam (Keppra), Tetrahedron: Asymmetry., 23, 1512 - 1515 (2012).
  • M. Muthukrishnan, M. Mujahid, M. Sasikumar And P. Mujumdar, First asymmetric synthesis of the antiepileptic drug Lacosamide (Vimpat) based on a hydrolytic kinetic resolution strategy, Tetrahedron: Asymmetry., 22, 1353 (2011).

Research Interest

Contact Details

Dr. M. Muthukrishnan


Scientist
Office: 206, Organic Chemistry Division
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone +91 20 2590 2284
Fax +91 20 2590 2629
E-mail m.muthukrishnan@ncl.res.in