Manish Kumar Mishra

Manish Kumar Mishra

Physical and Materials Chemistry Division

About Me

I work in the interdisciplinary areas of solid-state supramolecular chemistry, pharmaceuticals, and materials chemistry, which involves the synthesis of functional molecules, ionic liquids, molecular and pharmaceutical crystals, and responsive crystals. My research also focuses on investigating the structural origin of nanomechanics of organic crystals and their relationships with other physicochemical properties through crystal engineering.

Professional Experience

Scientist (Nov 2023 - Present), Physical and Material Chemistry Division, CSIR- National Chemical Laboratory, Pune, India

Assistant Professor (June 2021 - Nov 2023), Department of Chemistry, SAS, Vellore Institute of Technology (VIT University), Vellore, India

Postdoctoral Research Associate (Aug 2018 - May 2021), Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, USA (Advisor: Prof. C. Calvin Sun).

Postdoctoral Fellow (Sept 2017 - Aug 2018), College of Arts & Sciences, The University of Alabama, Tuscaloosa, Alabama, USA (Advisor: Prof. Robin D. Rogers)

Postdoctoral Fellow (May 2016 - May 2017), Department of Chemistry, McGill University, Montreal, Canada (Advisor: Prof. Robin D. Rogers).

Doctor of Philosophy Ph.D. (Aug 2011-March 2016) from Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore (Advisors: Prof. Gautam R. Desiraju and Prof. Upadrasta Ramamurty). 
Title of Thesis: Probing Mechanical Properties of Molecular Crystals with Nanoindentation: Applications to Crystal Engineering

M.Sc. in Organic Chemistry from Deen Dayal Upadhyay Gorakhpur University, India, Graduated in 2010.

B.Sc. in Chemistry and Physics from Deen Dayal Upadhyay Gorakhpur University, India, Graduated in 2008.

Selected Publications

  • Manish Kumar Mishra, * Pinki Mahur, Praveena Manimunda And Kamini Mishra, Recent Advances in Nanomechanical Measurements and Their Application for Pharmaceutical Crystals (Invited Review Article), Mol. Pharm., 20, 4848 - 4867 (2023).
  • Ragaverthini Chinnasamy, Bhushan Munjal, Raj Suryanarayanan, Abdul Malik P. Peedikakkal, Manish Kumar Mishra* And and Soumyajit Ghosh*, Pressure and Temperature Induced Dual Responsive Molecular Crystals: Effect of Polymorphism, Cryst. Growth Des., 22, 615 - 624 (2022).
  • Manish Kumar Mishra, Volodymyr Smetana, Ethan Hiti, Hannah, Wineinger, Fengrui Qu, Anja-Verena Mudring And Robin D. Rogers, CO2 capture from ambient air via crystallization with tetraalkylammonium hydroxides, Dalton Trans., 51, 17724 - 17732 (2022).
  • Soumyajit Ghosh and Manish Kumar Mishra* , Elastic Molecular Crystals: From Serendipity to Design to Applications (Review Article), Cryst. Growth Des., 21, 2566 - 2580 (2021).
  • Si-Fu Tang, Volodymyr Smetana, Manish Kumar Mishra, Steven P. Kelley, Olivier Renier, Robin D. Rogers And and Anja-Verena Mudring, Forcing Dicyanamide Coordination to f-Elements by Dissolution in Dicyanamide-based Ionic Liquids, Inorg. Chem., 59, 7227 - 7237 (2020).
  • Manish Kumar Mishra, Steven P Kelley, Volodymyr Smetana, David A. Dixon, Ashley S. McNeill, Anja-Verena Mudring And and Robin D. Rogers , Crystallographic Evidence of Watson-Crick Connectivity in The Base Pair of Anionic Adenine with Thymine, Proc. Natl. Acad. Sci. U.S.A., 117, 18224 - 18230 (2020).
  • Manish Kumar Mishra*, Kamini Mishra, Aditya Narayan, C. Malla Reddy* And and Venu R. Vangala*, Structural Basis for Mechanical Anisotropy in Polymorphs of a Caffeine–Glutaric Acid Cocrystal, Cryst. Growth Des., 20, 6306 - 6315 (2020).
  • Shenye Hu‡, Manish Kumar Misha‡ And and Changquan C. Sun, A twistable pharmaceutical crystal exhibiting exceptional plasticity and tabletability, Chem. Mater., 31, 3818 - 3822 (2019), DOI:(‡These authors contributed equally to this work) (Selected for the cover page of the journal).
  • Praveena Manimunda, Syed A. Asif And and Manish Kumar Mishra*, Probing stress induced phase transformation in aspirin polymorphs using Raman spectroscopy enabled nanoindentation, Chem. Commun., 55, 9200 - 9203 (2019).
  • Manish Kumar Mishra, Yogesh P. Patil, Steven P. Kelley And and Robin D. Rogers, A uranyl metal organic framework arising from the coordination of a partially hydrolyzed tetrauranyl node with the tautomerically diverse 1,4-(diamidoximyl)benzene ligand, Cryst. Growth Des., 19, 5466 - 5470 (2019).
  • Praveena Manimunda, Eric D. Hintsala And Syed Asif and Manish Kumar Mishra*, Mechanical anisotropy and pressure-induced structural changes in piroxicam crystals probed by in situ indentation and Raman Spectroscopy, JOM., 69(1), 57 - 63 (2017), DOI:(Selected for the cover page of the journal).
  • Manish Kumar Mishra, * Pallavi Prasanna Ghalsasi, M N Deo, Himal Bhatt, Himanshu Poswal And Soumyajit Ghosh and Somnath Ganguly, In-situ high pressure study of an elastic crystal by FTIR spectroscopy, CrystEngComm., 19, 7083 - 7087 (2017).
  • Manish Kumar Mishra, * Kamini Mishra And Syed A. Syed Asif and Praveena Manimunda, Structural analysis of elastically bent organic crystals by in situ indentation and micro-Raman spectroscopy, Chem. Commun., 53, 13035 - 13038 (2017).
  • Soumyajit Ghosh, ‡ Manish Kumar Mishra, ‡ Sourabh B. Kadambi And Upadrasta Ramamurty and Gautam R. Desiraju , Designing elastic organic crystals: Highly flexible polyhalogenated N-benzylidineanilines (‡These authors contributed equally to this work), Angew. Chem. Int. Ed., 54, 2674 - 2678 (2015).
  • Manish Kumar Mishra And Upadrasta Ramamurty and Gautam R. Desiraju, Solid solution hardening of molecular crystals: Tautomeric polymorphs of omeprazole, J. Am. Chem. Soc., 137, 1794 - 1797 (2015), DOI:(Highlighted in spotlights on J. Am. Chem. Soc. publications, DOI: 10.1021/jacs.5b01539).
  • Soumyajit Ghosh, Manish Kumar Mishra And Somnath Ganguly and Gautam R. Desiraju, Dual stress and thermally driven mechanical properties of the same organic crystal: 2,6-dichlorobenzylidene-4-fluoro-3-nitroaniline, J. Am. Chem. Soc., 137, 9912 - 9921 (2015).
  • Manish Kumar Mishra, Gautam R. Desiraju And Upadrasta Ramamurty and Andrew D. Bond, Studying microstructure in molecular crystals with nanoindentation: Intergrowth polymorphism in felodipine, Angew. Chem. Int. Ed., 53, 13102 - 13105 (2014).
  • Manish Kumar Mishra, Sunil Varughese And Upadrasta Ramamurty and Gautam R. Desiraju , Odd even effect in the elastic modulii of alhpa, omega-alkanedicarboxylic acids, J. Am. Chem. Soc., 135, 8121 - 8124 (2013).

Research Interest

  • Physical Chemistry
  • Materials Chemistry
  • Chemical Crystallography
  • Organic solid state reactions
  • Supramolecular Chemistry

Contact Details

Cabin no: 187, Physical/Materials Chemistry Division
CSIR-National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone: +91-20-25902091(office)