M. S. Shashidhar

M. S. Shashidhar

Organic Chemistry Division

About Me

Our research interest centers around the synthesis, associated reaction mechanisms and structure of inositols (cyclohexane hexols) and their derivatives. This is an important field related to carbohydrates, which has gained importance in the last two decades, due to the involvement of myo-inositol derivatives in various biological phenomena. We are developing efficient methods for the synthesis of biologically relevant, important inositol derivatives by (a) using myo-inositol orthoesters and inositol-1,3-acetals as early intermediates; (b) exploitation of the differences in chelation of metal ions by inositol derivatives to direct the selective O-substitution reaction of hydroxyl groups; (c) the use of one reaction - one product approach. Another area of our interest is the acyl transfer reactions in the crystalline state, which has implications on the reaction pathway for the addition of a nucleophile to a carbonyl group.

Professional Experience

  • 1992-todate- Scientist - National Chemical Laboratory, Pune.
  • 1987-1991- Post Doctoral Research Associate- University of Oregon, Eugene, OR, USA
  • 1987- Ph.D (Organic Chemistry) - Indian Institute of Science, Bangalore

Selected Publications

  • M. I. Tamboli, S. Krishnaswamy, R. G. Gonnade And M. S. Shashidhar, Identification of molecular crystals capable of undergoing acyl-transfer reaction based on intermolecular interactions in the crystal lattice, Chem. Eur. J., 19, 12867 - 12874 (2013).
  • R. C. Jagdhane, M. T. Patil, S. Krishnaswamy And M. S. Shashidhar, The orientation of the ?-hydroxyl group controls the diastereoselectivity during the hydride reduction and Grignard reaction of inososes, Tetrahedron., 69, 5144 - 5151 (2013).
  • B. P. Gurale, M. S. Shashidhar And R. G. Gonnade, Synthesis of the aminocyclitol units of (–) hygromycin A and methoxyhygromycin from myo-inositol, J. Org. Chem., 77, 5801 - 5807 (2012).
  • C. Murali, B. P. Gurale And M. S. Shashidhar, Intramolecular hydrogen abstraction in radicals derived from Inositol 1,3-acetals: efficient access to cyclitols. , Eur. J. Org. Chem., , 755 - 764 (2010).
  • R. C. Jagdhane And M. S. Shashidhar, Orthogonally protected cyclohexane hexols by ?one reaction ? one product? approach: efficient access to cyclitols and their derivatives, Eur. J. Org. Chem., , 2945 - 2953 (2010).

Research Interest

  • Catalysis AND NEW methods
  • Biomolecular Chemistry
  • NATURAL Products

Contact Details

Dr. M. S. Shashidhar


Senior Scientist 
Organic Chemistry Division
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone +91 20 2590 2055
Fax +91 20 2590 2629
E-mail ms.shashidhar@ncl.res.in