Subashchandrabose Chinnathambi

Subashchandrabose Chinnathambi

Biochemical Science Division

About Me

My undergraduate training was at the University of Madras, Madras and Bharathidhasan University where I obtained my Masters degree in Microbiology. During my research assistant training, I studied the viral capsid protein assembly and dis-assembly of Sesbania Mosaic Virus with Prof. H. S. Savithri and Prof. M. R. N. Murthy at the Indian Institute of Science (IISc), Bangalore. My doctoral training was with Prof. Dr. Eckhard Mandelkow in the Structural Molecular Biology at the Max Planck Institute, Hamburg where I examined the Influence of Phosphorylation on the Pathological Conformation of Human Microtubule Associated Protein – Tau in Alzheimer’s disease. For my postdoctoral training I worked with Prof. Dr. Eckhard Mandelkow at German Centre for Neurodegeneration Disease (DZNE)–Bonn and Max Planck Institute for Neurobiological Research-Hamburg Out station, Hamburg, Germany, studying the role of rare MAPT (p. A152T mutant) mutation increases the pathological conformation and physiological properties of Tau (axonal protein) in Alzheimer’s patient.

Professional Experience

  1. 2013 - Current: Scientist, National Chemical Laboratory, Pune, India.

 

  1. 2011-2013: Max Planck - Post Doctoral Research Fellow (with Prof. Dr. Eckhard Mandelkow, German Center for Neurodegenerative Disease (DZNE) - Bonn and Max Planck Institute for Neurobiological research (Hamburg-outstation), Hamburg and Bonn, Germany.

 

  1. 2007-2011: Ph.D Student (with Prof. Dr. Eckhard Mandelkow, Max Planck Institute for Structural Molecular Biology), Hamburg, Germany.

 

  1. 2005-2007: research assistant (with Prof. H. S. Savithri,Indian Institute of Science), Bangalore, India.

Selected Publications

  • Nalini Vijay Gorantla, Alexander V. Shkumatov And and Subashchandrabose Chinnathambi*, Conformational Dynamics of Intracellular Tau Revealed by Circular Dichorism and SAXS, Methods in Molecular Biology (MiMB- Tau Protein) Springer Publications., , (2017).
  • Nalini Vijay Gorantla, Puneet Kandelwal And Pankaj Poddar and Subashchandrabose Chinnathambi*, Microtubule-Associated Protein-Tau Conformation Mapped by Raman Spectroscopy, Methods in Molecular Biology (MiMB- Tau Protein) Springer Publications., , (2017).
  • Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*, Prion-like Propagation of Post-translationally Modified Tau in Alzheimer’s Disease (under review), Frontiers in Molecular Neuroscience., , (2017).
  • Batkulwar KB, Bansode SB, Patil GV, Godbole RK, Kazi RS, Chinnathambi Subashchandrabose, Shanmugam D And Kulkarni MJ, Investigation of Phosphoproteome in RAGE signaling, Proteomics., October, (2015), DOI:10.1002/pmic.201400169.
  • Coppola*, Chinnathambi Subashchandrabose*, et al. And , Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer’s disease, (First Author) - Human Molecular Genetics (HMG)., 21(15), 3500 - 3512 (2012), DOI:10.1093/hmg/dds161.
  • Daebel V, Chinnathambi Subashchandrabose #, Biernat J, Schwalbe M, Habenstein B, Loquet A, Müller H, Baldus M, Griesinger C, Zweckstetter M, Mandelkow E, Vijayan V And Lange A, Beta - Sheet core of tau paired helical filaments revealed by solid-state NMR, Journal of American Chemical Society (JACS)., 134(34), 13982 - 13989 (2012), DOI:10.1021/ja305470p.
  • Sadasivam J*, Chinnathambi Subashchandrabose*, Mandelkow Eva., and Mandelkow And E, Conformations of Microtubule-Associated Protein Tau mapped by fluorescence resonance energy transfer (FRET), First Author, Book Chapter - Methods in Molecular biology (Amyloid Proteins)., 849, 85 - 99 (2012), DOI:10.1007/978-1-61779-551-0_7.
  • Stefan B , Marco DM , Chinnathambi Subashchandrabose, Jacek B, Christian Griesinger , Eckhard Mandelkow And and Markus Zweckstetter , The Dynamic Structure of Filamentous Tau, Angewandte Chemistry, International Edition., 50, 11520 - 11524 (2011), DOI:10.1002/anie.201105493.
  • Shkumatov, A.V*., Chinnathambi Subashchandrabose*., Mandelkow, E., and Svergun And D.I, Structural memory of natively unfolded Tau protein detected by small-angle X-ray scattering (SAXS), First Author, Proteins., 79, 2122 - 2131 (2011), DOI:10.1002/prot.23033.
  • Wegmann, S., Jung, Y.J., Chinnathambi Subashchandrabose#., Mandelkow, E.M., Mandelkow, E., and Muller And D.J, Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability, COVER PAGE ARTICLE - Journal of Biological Chemistry (JBC)., 285, 27302 - 27313 (2010), DOI:10.1074/jbc.M110.145318.
  • Pappachan, A., Chinnathambi Subashchandrabose#, Satheshkumar, P.S., Savithri, H.S., and Murthy And M.R, A single point mutation disrupts the capsid assembly in Sesbania Mosaic Virus resulting in a stable isolated dimer, COVER PAGE ARTICLE - Virology., 392, 215 - 221 (2009), DOI:10.1016/j.virol.2009.06.047.
  • Jeganathan, S., Hascher, A., Chinnathambi Subashchandrabose, Biernat, J., Mandelkow, E.M., and Mandelkow And E, Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation, Journal of Biological Chemistry (JBC)., 283, 32066 - 32076 (2008), DOI:10.1074/jbc.M805300200.
  • Pappachan, A., Chinnathambi Subashchandrabose#, Satheshkumar, P.S., Savithri, H.S., and Murthy And M.R, Structure of recombinant capsids formed by the beta-annulus deletion mutant rCP (Delta48-59) of Sesbania mosaic virus, COVER PAGE ARTICLE - Virology., 375, 190 - 196 (2008), DOI:10.1016/j.virol.2008.01.023.

Research Interest

  • Human Diseases

Contact Details

Dr. Subashchandrabose Chinnathambi 


Assistant Professor AcSIR and Scientist 
Office: 1832, Biochemical Sciences Division 
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone - (O) +91 20 2590 2232

            (L) +91 20 2590 2227

Fax +91 20 2590 2648
E-mail s.chinnathambi@ncl.res.in