Sachin B. Agawane

Sachin B. Agawane

Biochemical Science Division

About Me

Current research interests:

•Pharmacokinetics and pharmacodynamics of New Chemical Entities (NCE) in laboratory animals.

 •Development and standardization of new animal models for various human diseases. e.g. Cancer Model, Diabetes Model, Arthritis Model, Anti-inflammatory Model etc.

•Efficacy and Preclinical Toxicity evaluation of synthetic and non-synthetic molecules in laboratory animals as per various guidelines like FDA, OECD, ICH, Schedule ‘Y’ and GLP principles.

Highlights of achievements:

•Established pathology laboratory at Poultry Diagnostic and Research Center, Hyderabad

 •Visionary, skillful and productive management Central Laboratory Animal House Facility of CSIR-IICT, Hyderabad as per national & international guidelines like CPCSEA, AAALAC, FELASA etc. Scientists and Researchers of IICT has been published many research papers and patents by use of this Central Laboratory Animal House Facility.

Total Scientific Publications: 37

Ten best publications:

1. Priyanka Singh, Ramesha H. Jayaramaiah, Sachin B. Agawane,Garikapati Vannuruswamy, Arvind M. Korwar, Atul Anand, Vitthal S. Dhaygude, Mahemud L. Shaikh, Rakesh S. Joshi, Ramanamurthy Boppana, Mahesh J. Kulkarni, Hirekodathakallu V. Thulasiram and Ashok P. Giri, Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights, Scientific Reports (2016), 6:18798

2.  Subrata Kumar Pore, Ashwani Choudhary, Bhowmira Rathore, Anirban Ganguly ,Pombala Sujitha, C. Ganesh Kumar, Sachin Bharat Agawane, Jerald Mahesh Kumar,Vinod Scaria, Beena Pillai, Rajkumar Banerjee, Hsp90-targeted miRNA-liposomal formulation for systemic antitumor effect, Biomaterials, (2013), 34, 6804-6817.

3.      Ramishetti Srinivas, Arup Garu, Gopikrishna Moku, Sachin B. Agawane, Arabinda Chaudhuri, A long-lasting dendritic cell DNA vaccination system using lysinylated amphiphiles with mannose-mimicking head-groups, Biomaterials, Volume 33, Issue 26, September 2012, Pg. 6220–6229.

4.    Tarak Nath Khatua, Raju Padiya, Santosh Karnewar, Madhusudana Kuncha, Sachin B. Agawane, Srigiridhar Kotamraju, Sanjay Kumar Banerjee, Garlic provides protection to mice heart against isoproterenol-induced oxidative damage: Role of nitric oxide, Nitric Oxide (2012),  27 (1) Pg. 9–17.

5.      Sristicheta Misra, Krishna Bihari Pandeya, Ashok Kumar Tiwari, Amtul Zehra Ali, Thimmapatruni Saradamani, Sachin Bharat Agawane, Kuncha Madhusudana, Antihyperglycemic, a-glucosidase inhibitory activities of some oxovanadium (IV) complexes: Examples of low IC50 values, International Journal of Nutrition and Metabolism (2012), 4 (1), pp. 11-18.  

6.   R. Nageswara Rao, Ganga Naidu, K. Guruprasad, P. Raju and Sachin B. Agawane, Determination of gemifloxacin on dried blood spots by hydrophilic interaction liquid chromatography with fluorescene detector: application to pharmacokinetics in rats, Biomedical Chromatography (2012), 26 (12), 1534-1542.

7.  P. V. Prabhakar, Utkarsh A. Reddy, S. P. Singh, A. Balasubramanyam, M. F. Rahman, S. Indu Kumari, Sachin B. Agawane, U. S. N. Murty, Paramjit Grover and Mohammed Mahboob, Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats,  Journal of Applied Toxicology ( 2012) 32: 436–445.

8.     Ashok K. Tiwari, K. Srikanth Reddy, Janani Radhakrishnan, D. Anand Kumar, Amtul Zehra, Sachin B. Agawane and K. Madhusudana, Influence of antioxidant rich fresh vegetable juices on starch induced postprandial hyperglycemia in rats, Food & Function (2011), 2, Pg.521-28. 

9.      R. Ranga Rao, A.K. Tiwari, P. Prabhakar Reddy, K. Suresh Babu, G. Suresh, A. Z. Ali,  K. Madhusudana,  Sachin B. Agawane, Preethi B., G. Narahari Sastry, J. M. Rao, Synthesis of antihyperglycemic, a-glucosidase inhibitory and DPPH free radical scavenging furanochalcones, 2011, Medicinal Chemistry Research, 10.1007/s00044-011-9583-7

10.  Sristicheta Misra, Krishna Bihari Pandeya, Ashok Kumar Tiwari, Amtul Zehra Ali,  Thimmapatruni Saradamani, Sachin Bharat Agawane, Kuncha Madhusudana, Antihyperglycemic, a-glucosidase inhibitory and DPPH free radical scavenging activity of 5-bromosalicylaldehyde and Schiff bases, Medicinal Chemistry Research (2011),20(9),1431- 37.

Professional Experience

1)Worked as a Scientist at CSIR- Indian Institute of Chemical Technology, Hyderabad, India. (August 2005 to August 2012).

2)Worked as a Assistant Manager in Venkateswara Hatcheries’ Poultry Diagnosis & Research Laboratory, Hyderabad (2004 to 2005).

3)Veterinary Officer, Raj Biotech, Wing, Satara, Maharashtra (1999 to 2000)

Selected Publications

Research Interest

  • Chemical Biology

Contact Details

Dr. Sachin B. Agawane
Biochemical Science Division
CSIR-National Chemical Laboratory
Pune- 411008 (INDIA)
Phone: +91-20- 25902714   Extension: 2714