Subhash P. Chavan

Subhash P. Chavan

Organic Chemistry Division

About Me

The research in Dr. Chavan’s group focus on the synthesis of biologically active compounds which include natural products, non-natural products and hybrid molecules. Another aspect which this group involves is the development of synthetic methodologies including custom designed methodologies and its application towards the synthesis of organic molecules. Asymmetric synthesis of biologically active molecules involving chirons as well as asymmetric synthesis including organocatalysts. Development of non-infringing processes for commercially important molecules. Process development, Custom synthesis and development of new chemical entities for antifungal applications.

Professional Experience

1) Sci-G:  August 2010-till date, CSIR-National Chemical Laboratory, Pune, India

2) Sci-F: August 2005 -2010, Organic Chemistry: Technology, NCL, Pune: 411 008, India

3) Sci-E-II, E-1 & #C: August 2000-2005, 1995-2000 & 1990-95, Organic Chemistry: Division, NCL, Pune: 411 008, India

4) Sc. Fellow: August 1989 - 1991, NCL, Pune: 411 008, India

5) Post-doc: Jan. 1986 - 1989, University of Minnesota, USA

    Advisor: Prof. Paul G. Gassman

6) Ph. D.: 1981 - 1985, National Chemical Laboratory, Pune :411 008, India. 

    Advisor: Dr. A. V. Rama Rao

7) M. Sc.: 1981, (Organic Chemistry) Department of Chemistry, University of Poona, Pune: 411 007, India

8) B.Sc.: 1979 (Chemistry) Fergusson College, University of Poona, Pune: 411 007, India

Selected Publications

  • Chavan S. P.; Garai S. ; Pawar K. P, "Asymmetric total synthesis of (-)-venlafaxine using an organocatalyst", Tetrahedron Letters., 54, 2137 - 2139 (2013).
  • Chavan S. P.; Harale K. R.; Pawar K. P, "A short synthesis of (2S, 3S)-3-hydroxypipecolic acid", Tetrahedron Letters., 54, 4851 - 4853 (2013).
  • Chavan S. P.; Lasonkar P. B, "One-pot migration-formylation of benzyl aryl ethers under Duff reaction condition", Tetrahedron Letters., 54, 4789 - 4792 (2013).
  • Chavan S. P.; Garai S. ; Dey C.; Gonnade R. G, "A highly stereocontrolled asymmetric total synthesis of epimer of (+)-7-deoxypancratistatin", Tetrahedron Letters., 54, 5562 - 5566 (2013).
  • Chavan S. P.; Lasonkar P.B.; Chavan P. N, "A novel and enantioselective synthesis of D-(+)-biotin via a Sharpless asymmetric dihydroxylation strategy", Tetrahedron Asymmetry., 24, 1473 - 1479 (2013).
  • Chavan S. P.; Lasonkar P.B, "pAaSimple Synthesis of the Novel Antihistaminic Drug Olopatadine Hydrochloride", Synthesis., 45, 3399 - 3403 (2013).
  • Chavan S. P.; Harale K. R.; Puranik V. G.; Gawade R. L, "Formal synthesis of (-)-stemoamide using a useful epimerization at C-8", Tetrahedron Letters., 53, 2647 - 2650 (2012).
  • Chavan S. P.; Harale K. R , "A very practical and selective method for PMB protection of alcohols", Tetrahedron Letters., 53, 4683 - 4686 (2012).
  • Chavan S. P.; Garai S. ; Kalkote U. R, "A highly diastereoselective total synthesis of (±)-Heritonin and (±)-Heritol", Tetrahedron., 68, 8509 - 8514 (2012).
  • Chavan S. P.; Khatod H. S, "Enantioselective synthesis of the essential oil and pheromonal component ar-himachalene by a chiral pool and chirality induction approach", Tetrahedron Asymmetry., 23, 1410 - 1415 (2012).
  • Chavan S. P.; Lasonkar P. B, "A chiral pool based approach to antipodes of alpha-cuparenone.", Tetrahedron Asymmetry., 23, 1496 - 1500 (2012).
  • Chavan S. P.; Garai S.; Dutta A. K.; Pal S, "Friedel–Crafts Acylation Reactions Using Esters", Eu. J. Org. Chem., 2012, 6841 - 6845 (2012), DOI:10.1002/ejoc.201201181.
  • Chavan S. P; Dumare N. B.; Harale K. R.; Kalkote U. R, "Asymmetric total synthesis of (2S,3S)-3-hydroxypipecolic acid", Tetrahedron Letters., 52, 404 - 406 (2011).
  • Panchgalle S. P.; Kunte S. S ; Chavan S. P. ; Kalkote U. R, "Exploration of L-proline catalyzed ?-aminoxylation of aldehyde towards (S)-guaifenesin related drug molecules", Syn. Commun., 41, 1938 - 1946 (2011).
  • Chavan S. P; Harale K. R.; Dumare N. B.; Kalkote U. R, "convenient formal synthesis of (2S,3S)-3-hydroxy pipecolic acid", Tetrahedron Asymmetry., 22, 587 - 590 (2011).
  • Chavan S. P; Dhawane A. N.; Kalkote U. R. , "Formal synthesis of (±)-camptothecin via tricyclic lactone as key synthon", Tetrahedron Letters., 51, 3099 - 3101 (2010).
  • Panchgalle S. P.; Bidwai H. B. ; Chavan S. P.; Kalkote U. R, "Organocatalytic asymmetric synthesis of (-)-delta-coniceine based on sequential proline-catalyzed asymmetric alpha-amination-HWE olefination", Tetrahedron Asymmetry., 21, 2399 - 2401 (2010).
  • Chavan S. P; Pathak A. B.; Pandey A.; Kalkote U. R, "Short and efficient synthesis of rubrolide E", Syn. Commun., 38, 3143 - 3149 (2008).
  • Chavan S. P; Thakkar M.; Kalkote U. R. And , "The first enantiospecific synthesis of (-)-heritol: absolute configuration determination", Tetrahedron Letters., 48, 643 - 646 (2007).