Sandip S. Shinde

Sandip S. Shinde

Organic Chemistry Division

About Me

Our laboratory research mainly focus on synthesis of industrial important terpene and alkaloids natural products, 

Synthesis of polyprenyl-pyrophosphate as a precursor for Chemo-Enzymatic reactions to elucidate the cyclization mechanism of terpene cyclase. 

Developing new Fluorination reactions to introduce fluorine on aliphatic/aromatic substrates, and their application in radiopharamaceutical industry.


Professional Experience

2013 Assistant Professor (AcSIR), Scientist Fellow, CSIR-National Chemical Laboratory, Pune, India

2012 Senior Research Scientist, Syngene International Ltd. (A Biocon company), Bangalore, India.

JSPS-Postdoctoral Fellow, Hokkaido University, Japan

Ph.D., Inha University, S. Korea

Selected Publications

  • Sandip S. Shinde, T. Ozaki, L. Gao, R. Okuizumi, C. Liu, Y. Ogasawara, X. Lei, T. Dairi, A. Minami And H. Oikawa, Enzymatic construction of skipped methyl-substituted octaprenyl side chain of longestin (KS-505a): Involvement of homoIPP as a common extender unit, Angew. Chem. Int. Ed. (accepted)., , (2018), DOI:
  • M. S. Said, L. Khandare And Sandip S. Shinde, Molybdenum oxide-mediated facile aliphatic nucleophilic fluorination, Tetrahedron Letters., 58, 59 - 62 (2017), DOI:
  • Sandip S. Shinde, A. Minami, Z. Chen, T. Tokiwano, T. Toyomasu, N. Kato, T. Sassa And H. Oikawa, Elucidation of the cyclization mechanism of terpene synthases: Mass spectrometry based analysis of various site-specifically labeled terpenes, The J. Antibiotics (Nature publication)., 70, 632 - 638 (2017), DOI:10.1038/ja.2017.27.
  • Shinde S. S., * Navale G. R., Said S.M. And Thulasiram HV, Stereoselective quenching of cedryl carbocation in epicedrol biosynthesis, Tetrahedron Letters., 57, 1161 - 1164 (2016), DOI:10.1016/j.tetlet.2016.01.109.
  • SANDIP S SHINDE, Mahesh S. Dharne And Govinda Navale , Antibioflim Activity of tert-BuOH Functionalized Ionic Liquids with Methylsulfonate counteranion, RSC Advances., 5, 68136 - 68142 (2015), DOI:10.1039/C5RA12854D.
  • S. S. Thakur, D. Patel, G. R. Kurrey, SANDIP S SHINDE, P. Kumar And G-J Kim , Dinuclear salen Cobalt complex incooperated Y(OTf)3: Enhanced enantioselectivity in hydrolytic kinetic resolution of epoxides, RSC Advances., 5, 82699 - 82703 (2015), DOI:10.1039/C5RA12408E.
  • Sandip S. Shinde* And Sunil N.Patil , One Molecule of Ionic Liquid and tert-Alcohol on Polystyrene-Support as Catalysts for Efficient Nucleophilic Substitution Including Fluorination, Org. Biomol. Chem., 12, 9264 - 9271 (2014).
  • A.Minami, M. G.Suzuki, M.Akira, Shinde S. Sandip, K.Sato, K.Wantanbe, T.Ose, H.Oguri, T.Tamura, H.Oikawa And , Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis, J. Am. Chem. Soc., 134, 7246 - 7249 (2012).
  • O.Ariyawutthiphan, T.Ose, A.Minami, Shinde S. Sandip, M.Tsuda, Y.-G.Gao, M.Yao, H.Oikawa And I.Tanaka, Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation, Acta Crystallographica Section D., D68, 1558 - 1569 (2012).
  • Sandip S. Shinde, B.S. Lee And D.Y. Chi, Synergistic effect of Two Solvents, tert-Alcohol and Ionic Liquid, in One Molecule in Nucleophilic Fluorination, Org. Letters., 10, 733 - 735 (2008).

Research Interest

  • Organic Chemistry

Contact Details

Dr. Sandip S. Shinde

Room no. 343, Main building
Organic Chemistry Division
CSIR-National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone +91 20 2590 2329