Sandip S. Shinde

Organic Chemistry Division

About Me

Our laboratory research mainly focus on synthesis of industrial important terpene and alkaloids natural products,

Synthesis of polyprenyl-pyrophosphate as a precursor for Chemo-Enzymatic reactions to elucidate the cyclization mechanism of terpene cyclase.

Developing new Fluorination reactions to introduce fluorine on aliphatic/aromatic substrates, and their application in radiopharamaceutical industry.

Professional Experience

2013 Assistant Professor (AcSIR), Scientist Fellow, CSIR-National Chemical Laboratory, Pune, India

2012 Senior Research Scientist, Syngene International Ltd. (A Biocon company), Bangalore, India.

JSPS-Postdoctoral Fellow, Hokkaido University, Japan

Ph.D., Inha University, S. Korea

Selected Publications

Sandip S. Shinde, T. Ozaki, L. Gao, R. Okuizumi, C. Liu, Y. Ogasawara, X. Lei, T. Dairi, A. Minami And H. Oikawa, Enzymatic construction of skipped methyl-substituted octaprenyl side chain of longestin (KS-505a): Involvement of homoIPP as a common extender unit, Angew. Chem. Int. Ed. (accepted)., 57, 6629 - 6632 (2018), DOI:https://doi.org/10.1002/anie.201802116.
Rohini N. Udavant, Ashok R. Yadav And Sandip S. Shinde*, One-pot Sequential Bromination and Fluorination to Access 3- Fluoroimidazo[1, 2-a]pyridines from Arylketones, Eur J. Org. Chem., 2018, 3432 - 3436 (2018), DOI:org/10.1002/ejoc.201800578.
M. S. Said, L. Khandare And Sandip S. Shinde, Molybdenum oxide-mediated facile aliphatic nucleophilic fluorination, Tetrahedron Letters., 58, 59 - 62 (2017), DOI:http://dx.doi.org/10.1016/j.tetlet.2016.11.099.
Sandip S. Shinde, A. Minami, Z. Chen, T. Tokiwano, T. Toyomasu, N. Kato, T. Sassa And H. Oikawa, Elucidation of the cyclization mechanism of terpene synthases: Mass spectrometry based analysis of various site-specifically labeled terpenes, The J. Antibiotics (Nature publication)., 70, 632 - 638 (2017), DOI:10.1038/ja.2017.27.
Shinde S. S., * Navale G. R., Said S.M. And Thulasiram HV, Stereoselective quenching of cedryl carbocation in epicedrol biosynthesis, Tetrahedron Letters., 57, 1161 - 1164 (2016), DOI:10.1016/j.tetlet.2016.01.109.
SANDIP S SHINDE, Mahesh S. Dharne And Govinda Navale , Antibioflim Activity of tert-BuOH Functionalized Ionic Liquids with Methylsulfonate counteranion, RSC Advances., 5, 68136 - 68142 (2015), DOI:10.1039/C5RA12854D.
S. S. Thakur, D. Patel, G. R. Kurrey, SANDIP S SHINDE, P. Kumar And G-J Kim , Dinuclear salen Cobalt complex incooperated Y(OTf)3: Enhanced enantioselectivity in hydrolytic kinetic resolution of epoxides, RSC Advances., 5, 82699 - 82703 (2015), DOI:10.1039/C5RA12408E.
Sandip S. Shinde* And Sunil N.Patil , One Molecule of Ionic Liquid and tert-Alcohol on Polystyrene-Support as Catalysts for Efficient Nucleophilic Substitution Including Fluorination, Org. Biomol. Chem., 12, 9264 - 9271 (2014).
A.Minami, M. G.Suzuki, M.Akira, Shinde S. Sandip, K.Sato, K.Wantanbe, T.Ose, H.Oguri, T.Tamura, H.Oikawa And , Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis, J. Am. Chem. Soc., 134, 7246 - 7249 (2012).
O.Ariyawutthiphan, T.Ose, A.Minami, Shinde S. Sandip, M.Tsuda, Y.-G.Gao, M.Yao, H.Oikawa And I.Tanaka, Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation, Acta Crystallographica Section D., D68, 1558 - 1569 (2012).
Sandip S. Shinde, B.S. Lee And D.Y. Chi, Synergistic effect of Two Solvents, tert-Alcohol and Ionic Liquid, in One Molecule in Nucleophilic Fluorination, Org. Letters., 10, 733 - 735 (2008).

Research Interest

Organic Chemistry

Contact Details

Dr. Sandip S. Shinde

Room no. 343, Main building
Organic Chemistry Division
CSIR-National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India
Phone +91 20 2590 2329