Our group research interests are in the field of total synthesis and drug discovery research, with an ultimate aim of discovering drugs. In addition, identifying small molecules for crop protection is also of significant interest. We have accomplished the synthesis of 20 natural products which include cell-adhesion inhibitors, antibacterial, anti-inflammatory, anti-cancer agents and insect repellents. In the medicinal chemistry front, several programs have been initiated with collaborations from academia and industry. In particular, significant progress has been made using a new concept called “Silicon-switch approach”. The research work conducted over the last five years at NCL was published in 30 papers and resulted in 24 patent filings. The highlights are summarized below.

 Total Synthesis of Natural Products Using Scalable Routes            

The list of synthesized natural products from this group during the last 5 years is shown here along with their biological activities and publication details. Some of these projects are being converted to medicinal chemistry programs.

  Medicinal Chemistry Using Silicon - Switch Approach                    

 Strategic incorporation of Silicon into known drugs / drug-like compounds in search for novel drugs is an
 interesting approach. Unlike Deuterium incorporation, it is underexplored

  - Minimum  risk, improved biological properties and a clear IP position

 The increased lipophilicity of organosilicon molecules often enhances cell and tissue penetration which can be an
 attractive feature in the design of drugs targeting bacteria and central nervous system. 

 We already have identified several molecules in three different series which can be taken forward towards further development

 - Linezolid Series:
   Identified NDS-10024, NDS-10028 and NDS-10062 as lead-like compounds with excellent brain exposures

 - Diarylpyrrole Series:
   Identified nano-molar compounds (NDS-100244) against TB with profile comparable to BM212
 
 - Diarylpyrazole Series:
    Identified nano-molar compounds (NDS-100529) against TB with improved potency comparable to BM212

  We have plans to profile these compounds in animal models, in particular brain infection models. 
  Looking for the collaborators to take forward identified hits…. 
 
 
 
 

  Access to Enantiopure Pheromones Towards Crop Protection        

 As part of our research interests towards crop protection, recently his group has synthesized an optically pure sex pheromone that can be used to control mealybug      population in farms, vineyards, green houses, etc. 

 

 Selected Publications                                                                         


1. Total Synthesis and Structural Revision of Mycalol, an Anticancer Natural Product from the Marine Source; B. Seetharamsingh, P.R. Rajamohanan, and D. Srinivasa      Reddy*  Org. Lett., 2015, 17 (7), pp 1652–1655. DOI: 10.1021/acs.orglett.5b00345.


 2. Total Synthesis of Deoxy-solomonamide B by Mimicking Biogenes; N. Vasudevan, K. Kashinath and D. Srinivasa Reddy*; Org. Lett., 2014, 16 (23), pp 6148–6151. DOI: 10.1021/ol503011g

    

3. Total Synthesis of (±)-Nardoaristolone B and Its Analogues; Kishor L. Handore and D. Srinivasa Reddy*; Org. Lett.201416 (16), pp 4252–4255.DOI10.1021/ol501949r


 

4. First Total Synthesis of Hunanamycin A; Rahul D.Shingare, R.Velayudham, Jalindar R.Gawade and D. Srinivasa Reddy*; Org. Lett., 2013, 16 (17), pp 4556-4559. DOI10.1021/ol402110e

 

 5. A Diverted Total Syntheses of Potent Cell Adhesion Inhibitor Peribysin E Analogues; Kishor L.Handore and D. Srinivasa Reddy*. Org. Lett.201315 (8), pp 1894–  1897. DOI10.1021/ol40055m

  

6. Syntheses and Determination of Absolute Configurations and Biological Activities of the Enantiomers of the Longtailed Mealybug Pheromone; Remya Ramesh, Pandrangi Siva Swaroop, Rajesh. G. Gonnade, Choppari Thirupathi, Rebeccah A. Waterworth, Jocelyn G. Millar, D. Srinivasa Reddy*; J. Org. Chem., 2013, 78 (12), pp 6281–6284. DOI: 10.1021/jo400491n


 

7. Synthesis of Palmyrolide A and its cis-isomer and mechanistic insight into trans-cis isomerisation of the enamide macrocycle; Satish Chandra Philkhana, B. Seetharam Singh, Yuvraj B. Dangat, Kumar Vanka, D. Srinivasa Reddy* ; Chem. Commun., 2013, 49, 3342-3344. DOI: 10.1039/c3cc40541A



 

8. Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues; Pandrangi Siva Swaroop, Gajanan N. Raut, Rajesh G. Gonnade, Priyanka Verma, Rajesh S. Gokhale, D. Srinivasa Reddy*; Org. Biomol. Chem., 2012,10, 5385-5394. DOI: 10.1039/C2OB25831E


9. Synthesis of Molluscicidal Agent Cyanolide A from D-(-)-Pantolactone; Atul K. Hajare, Velayutham Ravikumar, Shaik Khaleel,Debnath Bhuniya, D. Srinivasa Reddy*; J. Org. Chem., 2011, 76(3), pp 963-966. DOI: 10.1021/jo101782q



10. A  General Approach Toward Bakkanes: Short Synthesis of (±)-Bakkenolide-A (Fukinanolide); D. Srinivasa Reddy*; Org. Lett., 2004, 6 (19), pp 3345–3347. DOI: 10.1021/ol048726d



 

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