Dr. Ravindar Kontham’s Research Group

Welcome to our website! Our research group actively working in the areas of organic synthesis and medicinal chemistry. Our main research focus is on cool projects like practical stereo-selective total synthesis of complex biologically potent natural products and medicinal chemistry. We investigate to prepare more potent, less toxic and structurally simplified analogues of various complex natural products via structural modification of parent natural molecules. We also work on development of new synthetic methodologies involving alkyne cycloisomerization and cascade polycyclizations. 

Natural products have long been regarded as ‘nature’s medicine chest’ providing a rich source of lead compounds as invaluable platforms for developing front-line drugs. 63% of all new drugs approved by the FDA between 1981 and 2006 were inspired by natural products. Our research focuses on making and modifying naturally occurring bioactive compounds that have been isolated from plants, animal tissue, microbes or marine and soil organisms, which are rare or hard to isolate in abundance. These compounds provide rich and diverse chemical structures that challenge the synthetic chemist to develop new flexible synthetic methodology for their construction. The preparation of synthetic analogues of the natural compound may improve the biological activity and provide an understanding of the mechanism of action of the naturally occurring compound.



 Recent Publications of our group

Completed Targets

Stereoselective Total Synthesis of (±)-Pleurospiroketals A and B

Thorat, S. S.; Gamidi, R.; Kontham, R. J. Org. Chem.202186, 13572―13582.


Bismuth(III)-catalyzed bis-cyclization of propargylic diol-esters: a unified approach for the synthesis of  [5,5]- and [6,5]-oxaspirolactones

Kambale, D. A.; Borade, B. R.; Kontham, R. Org. Biomol. Chem., 2021, 19, 6618-6622.


Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products  

 Thorat, S. S.; Kontham, R. Org. Chemfront2021, 8, 2110-2162.



Total Synthesis of Beshanzuenone D & It's Epimers and Abiespiroside A  

 Borade, B. R.; Ruchi Dixit,; Kontham, R. Org. Lett., 2020, 22, 8561-8565.

 DOI: https://dx.doi.org/10.1021/acs.orglett.0c03157


Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

 Thorat, S. S.; Kontham, R. Org. Biomol. Chem., 2019, 17, 7270-7292.

  DOI: 10.1039/c9ob01212e.


TiCl4-n-Bu3N-mediated cascade annulation of ketones with α-ketoesters: a facile synthesis of highly substituted fused γ-alkylidene-butenolides

 Palange, M. N.; Gonnade, R. G.; Kontham, R. Org. Biomol. Chem., 2019, 17, 5749-5759.                               

DOI: 10.1039/c9ob00649d

Fe(III)-Catalyzed Diastereoselective Friedel−Crafts Alkylation− Hemiketalization−Lactonization Cascade for the Synthesis of Polycyclic Bridged 2‑Chromanol Lactones

 Borade, B. R.; Nomula, R.; Gonnade, R. G.;  Kontham, R. Org. Lett.,  2019, 21, 2629-2633.                           

DOI: 10.1021/acs.orglett.9b00614


Four-Step Total Synthesis of (+)-Yaoshanenolides A and B

 Thorat, S. S.; Palange, M. N.; Kontham, R. ACS Omega 2018, 3, 7036-7045. 

 DOI: 10.1021/acsomega.8b00701

Bismuth(III)-catalyzed cycloisomerization and (hetero)arylation of alkynols: a simple access to 2-(hetero)aryl tetrahydrofurans and tetrahydropyrans

 Nakate, A. K.; Pratapure, M. S.; Kontham, R. Org. Biomol. Chem., 2018, 16, 3229-3240.

 DOI: 10.1039/c8ob00368h                                                                        


Synthesis of Furo[2,3‑b]pyran-2-ones through Ag(I)- or Ag(I)−Au(I)-Catalyzed Cascade Annulation of Alkynols and α‑Ketoesters

Thorat, S. S.; Kataria, P.; Kontham, R. Org. Lett. 2018, 20, 872-875.

 DOI: 10.1021/acs.orglett.7b04027 


Lewis acid catalyzed cascade annulation of alkynols with α ketoesters: a facile access to γ-spiroketal-γ-lactones

Kambale, D. A.; Thorat, S. S.; Pratapure, M. S.; Gonnade, R. G.;  Kontham, R. Chem. Commun., 2017, 53, 6641-6144.  



Contact Details:
Dr. Ravindar Kontham
Principal Scientist-CSIR/Associate Professor-AcSIR
Division of Organic Chemistry
CSIR-National Chemical Laboratory
Dr. Homi Bhabha Road
Pune-411008, India.
Phone Office: +91-20-2590 2301
Mobile: +91 750 788 9557
e-mail: k.ravindar@ncl.res.in