Asish K. Bhattacharya

Asish K. Bhattacharya

Organic Chemistry Division

About Me

Research in our group involves identification of bioactives from natural sources and development of novel strategies for the synthesis of biologically active molecules


v  Identification of bioactive compounds from medicinal   plants/microbes

Natural products represent the richest source of novel molecular scaffolds and chemistry. The chemical diversity of natural products has guided the drug discovery research worldwide. Bioassay guided isolation of secondary metabolites from plants and microbes and structure elucidation remain an important area of research in our lab towards identification of new leads.

 

v  Development of new methodologies for the synthesis of bioactive molecules

Our group is working on development of synthetic methodologies for the synthesis of bioactives as well as late stage functionalization of natural products to enhance bioactivities. Our synthetic studies are mainly directed towards new therapeutics for parasitic diseases and anticancer agents.

Professional Experience

June 2005 - present: Scientist, Division of Organic Chemistry, CSIR-NCL, Pune

1999-2001: DAAD fellow, Fachberiech Chemie, Universitaet Konstanz, Germany
Mentor: Prof. Dr. Richard R. Schmidt

1994-1998: Ph.D., Phytochemical Technology Division, CSIR-Central Institute of Medicinal Plants (CSIR-CIMAP), Lucknow
Mentor: Dr. Ram P. Sharma


Selected Publications

  • L. Goswami, S. Paul. T. K. Kotammagari And A. K. Bhattacharya*, Synthesis of artemisinin derived glycoconjugates inspired by click chemistry, New J. Chem., 43, 4017 - 4021 (2019).
  • S. Paul And A. K. Bhattacharya*, Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions, Org. Biomol. Chem., 16, 444 - 451 (2018).
  • T. R. Valkute, E. K. Aratikatla, N. Gupta, S. Ganga, M. K. Santra And A. K. Bhattacharya*, Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea, RSC Advances., 8, 38289 - 38304 (2018).
  • T. K. Kotammagari, R. G. Gonnade And A. K. Bhattacharya*, Biomimetic total synthesis of angiopterlactone B and other potential natural products, Org. Lett., 19(13), 3564 - 3567 (2017).
  • E. K. Aratikatla, T. R. Valkute, S. K. Puri, K. Srivastava And A. K. Bhattacharya*, Norepinephrine alkaloids as antiplasmodial agents: Synthesis of syncarpamide and insight into the structure-activity relationships of its analogues as antiplasmodial agents, Eur. J. Med. Chem., 138, 1089 - 1105 (2017).
  • H. R. Chand And A. K. Bhattacharya*, Diastereoselective synthesis of ?-ether derivatives of artemisinin, an antimalarial drug: The effect of nitrile on stereoselectivity, Asian J. Org. Chem., 5(2), 5802 - 5803 (2016).
    Back Cover Page Article
  • T. K. Kotammagari, R. G. Gonnade And A. K. Bhattacharya*, Synthesis of naturally occurring (+)-osmundalactone and 4-epi-(+)-osmundalactone from triacetyl-O-D-glucal, Tetrahedron Lett., 56, 2783 - 2786 (2015).
  • E. K. Aratikatla And A. K. Bhattacharya*, Chiral pool approach for the synthesis of functionalized amino acids: Synthesis of antiepileptic drug (R)-Lacosamide, Tetrahedron Lett., 56, 5802 - 5803 (2015).
  • I. K. Polanki, S. H. Kurma And A. K. Bhattacharya*, Direct glycosylation of unprotected and unactivated sugars using bismuth nitrate pentahydrate, J. Carbohydr. Chem., 34, 196 - 205 (2015).
  • A. K. Bhattacharya, * H. R. Chand, J. John And M. V. Deshpande, Clerodane type diterpene as a novel antifungal agent from Polyalthia longifolia var. pendula, Eur. J. Med. Chem., 94, 1 - 7 (2015).
  • A. K. Bhattacharya, * D. S. Raut, K. C. Rana, I. K. Polanki, M. S. Khan And S. Iram, Diversity-oriented synthesis of ?-aminophosphonates: a new class of potential anticancer agents, Eur. J. Med. Chem., 66, 146 - 152 (2013).
  • A. K. Bhattacharya, * K. C. Rana, C. Pannecouque And E. De Clercq, An efficient synthesis of a hydroxyethylamine (HEA) isostere and its ?-aminophosphonate and phosphoramidate derivatives as potential anti-HIV agent, ChemMedChem., 7, 1601 - 1611 (2012).
  • A. K. Bhattacharya* And K. C. Rana, Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors, Bioorg. Med. Chem., 19, 7129 - 7135 (2011).
  • A. K. Bhattacharya, * K. C. Rana, D. S. Raut, V. P. Mhaindarkar And M. I. Khan, An efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction, Org. Biomol. Chem., 9, 5407 - 5413 (2011).
    Front Cover Page Article
  • A. K. Bhattacharya, * T. Kaur And K. N. Ganesh, Synthesis of the antibacterial benzoquinone primin and its water-soluble analogue, primin acid, Synthesis., , 1141 - 1144 (2010).
  • A. K. Bhattacharya, * K. C. Rana, M. Mujahid, I. Sehar And A. K. Saxena, Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents, Bioorg. Med. Chem. Lett., 19, 5590 - 5593 (2009).
  • A. K. Bhattacharya And * K. C. Rana, Amberlite-IR 120 catalyzed three-component synthesis of ?-amino phosphonates in one-pot, Tetrahedron Lett., 49(16), 2598 - 2601 (2008).
  • A. K. Bhattacharya, * M. A. Diallo And K. N. Ganesh, SbCl3 as a highly efficient catalyst for the acetylation of alcohols, phenols and amines under solvent-free conditions, Synth. Commun., 38, 1518 - 1526 (2008).
  • A. K. Bhattacharya, * M. Mujahid And A. A. Natu, An efficient method for the synthesis of acylals from aldehydes under solvent-free conditions catalysed by antimony trichloride, Synth. Commun., 38, 128 - 134 (2008).
  • A. K. Bhattacharya And * K. C. Rana, Microwave assisted synthesis of 14-aryl-14H-dibenzo[a.j]xanthenes catalysed by methanesulphonic acid under solvent-free condition, Mendeleev Commun., 17(4), 247 - 248 (2007).
  • A. K. Bhattacharya And * T. Kaur, An efficient one-pot synthesis of ?-amino phosphonates catalyzed by bismuth nitrate pentahydrate, Synlett., , 745 - 748 (2007).
  • A. K. Bhattacharya, * A. K. Pathak And R. P. Sharma, Semi-synthesis of deoxyartemisinin, Mendeleev Commun., 17(1), 27 - 28 (2007).
  • A. K. Bhattacharya, * M. Pal, D. C. Jain, B. S. Joshi, R. Roy, U. Rychlewska And R. P. Sharma, Stereoselective reduction of arteannuin B and its chemical transformations. A. K. Bhattacharya,* M. Pal, D. C. Jain, B. S. Joshi, R. Roy, U. Rychlewska and R. P. Sharma, Tetrahedron., 59(16), 2871 - 2876 (2003).
  • A. K. Bhattacharya, F. Stolz, J. Kurzeck, W. Rueger And R. R. Schmidt, Structure-based design, synthesis and in vitro evaluation of substituted aryl/hetaryl methyl phosphonate and phosphate - UMP derivatives as potential glucosyltransferase inhibitors, Can. J. Chem., 80(8), 973 - 982 (2002).
  • A. K. Bhattacharya, F. Stolz, J. Kurzeck, W. Rueger And R. R. Schmidt, SAR directed design and synthesis of novel ?(1-4)-glucosyltransferase inhibitors and their in vitro inhibition studies, Bioorg. Med. Chem., 10(4), 1129 - 1136 (2002).
  • A. K. Bhattacharya, F. Stolz And R. R. Schmidt, Design and synthesis of aryl/hetarylmethyl phosphonate-UMP derivatives as potential glucosyltransferase inhibitors, Tetrahedron Lett., 42, 5393 - 5395 (2001).
  • A. K. Bhattacharya And R. P. Sharma, Recent developments on the chemistry and biological activity of artemisinin and related antimalarials- an update, Heterocycles., 51, 1681 - 1745 (1999).
  • A. K. Bhattacharya, D. C. Jain And R. P. Sharma, Selective reduction of the exomethylene group of ?-methylene ?- or ?-lactones with CdCl2-Mg-MeOH-H2O, J. Chem. Res. (S)., , 768 - 769 (1998).
  • A. K. Bhattacharya, D. C. Jain, R. P. Sharma, R. Roy And A. T. McPhail, Boron trifluoride-acetic anhydride catalysed rearrangement of dihydroarteannuin B, Tetrahedron., 53(44), 14975 - 14990 (1997).

Research Interest

  • NATURAL Products

Contact Details

Office: Room No. 343, Second Floor Main Building
Lab.: Room No. 347, Second Floor Main Building