Our group, the Metabolic Inquiry and Cellular Engineering (MICE)
group, uses systems approaches (both experimental and computational) to
understand biological cell behavior and function. We build computer
models of the cell through genome-scale metabolic network
reconstruction and compute cell phenotype using Constraints-based
modeling and flux balance analysis. Experimental approaches in
prokaryotes involve genome-engineering of Escherichia coli for
value added chemicals using recombinant and synthetic biology
techniques. Fundamental growth and proliferation studies on lung
adenocarcinoma and glioblastoma cells are in progress to understand
and implicate key players in metabolism.
We strive to practice model-driven science by validation of in silico discoveries experimentally at different levels of molecular organization in both prokaryotic and eukaryotic systems.