Our group, the Metabolic Inquiry and Cellular Engineering (MICE) group, uses systems approaches (both experimental and computational) to understand biological cell behavior and function. We build computer models of the cell through genome-scale metabolic network reconstruction and compute cell phenotype using constraints-based flux balance analysis. Experimental approaches in prokaryotes involve genome-engineering of Escherichia coli for value added chemicals using recombinant and synthetic biology techniques. 

Our goals include understanding drug resistance both in antibiotic resistant pathogens and also in chemo-resistant cancer cells. We foresee clinical application in tailoring micro-environments to overcome the problem of drug resistance.

We strive to practice model-driven science by validation of  in silico discoveries experimentally at different levels of molecular organization in both prokaryotic and eukaryotic systems.

For more details visit our Metabolic Inquiry and Cellular Engineering (MICE) Lab web page.

https://sites.google.com/micelabatncl