Ravindar Kontham

Ravindar Kontham

Organic Chemistry Division

About Me

 

Welcome to our website! We are a new group of graduate and undergraduate students doing research in the areas of organic synthesis and medicinal chemistry. Our main research focus is on cool projects like practical stereo-selective total synthesis of complex biologically potent natural products and medicinal chemistry. We investigate to prepare more potent, less toxic and structurally simplified analogues of various complex natural products via structural modification of parent natural molecules. We also working on development of new synthetic methodologies involving alkyne cycloisomerization and cascade polycyclizations.

Professional Experience

  1.   Sep.-2014-Current: Senior Scientist, Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune, India.
  2.       Dec.-2013-Sept.-2014: Senior Research Scientist, Toronto Research Chemicals Inc (TRC). Toronto, Canada (A Premier Contract Research Organization in Canada).
  3.      July-2010-Nov.-2013: Post-Doctoral Fellow (NSERC Canada), with Prof. Pierre Deslongchamps, Department of Chemistry, UNIVERSITÉ LAVAL, Québec (Québec), Canada.
  4.      Dec.-2008-June-2010: Post-Doctoral Fellow (NSERC Canada), with Prof. Pierre Deslongchamps, Department of Chemistry, UNIVERSITÉ DE SHERBROOKE, Sherbrooke, Québec, Canada.
  5.        April-2003-Nov.-2008: Junior Research Fellow & Senior Research Fellow-CSIR, India, under the supervision of Dr. J. S. Yadav, Former Director, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
  6.        June-2002-March-2003: Dr Reddy’s Research Foundation (DRF), Dr Reddy’s Laboratories, Hyderabad, India.

Selected Publications

  • Digambar A. Kambale, Sagar S. Thorat, Madhukar S. Pratapure, Rajesh G. Gonnade And and Ravindar Kontham*, Lewis acid catalyzed cascade annulation of alkynols with a-ketoesters: A facile access to g-spiroketal-g-lactones, Chem Commun., 53, 6641 - 6644 (2017), DOI:10.1039/C7CC03668J.
  • Kontham Ravindar, Pierre-Yves Caron And and Pierre Deslongchamps, Anionic Polycyclization Entry to Tricycles Related to Quassinoids and Terpenoids: A Stereocontrolled Total Synthesis of (+)-Cassaine, J. Org. Chem., 79, 7979 - 7990 (2014).
  • Ragam Somaiah, Kontham Ravindar, Regina Cencic And Jerry Pelletier and Pierre Deslongchamps, Synthesis of the Antiproliferative Agent Hippuristanol and Its Analogues from Hydrocortisone via Hg(II)-Catalyzed Spiroketalization: Structure-Activity Relationship, J. Med. Chem., 57, 2511 - 2523 (2014).
  • Kontham Ravindar, Pierre-Yves Caron And and Pierre Deslongchamps, Total Synthesis of (+)-Cassaine Utilizing an Anionic Polycyclization Strategy, Org. Lett., 15, 6270 - 6273 (2013).
  • Zeina Nasr, Lukas E Dow, Marilene Paquet, Jennifer Chu, Kontham Ravindar And Ragam Somaiah, Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia, BMC Pharmacology and Toxicology., 14, (2013).
  • R Cencic, F Robert, G Galicia-Vazquez, A Malina, K Ravindar, R Somaiah, J Tanaka, P Deslongchamps And and J Pelletier, Modifying Chemotherapy Response by Targeted Inhibition of Eukaryotic Initiation Factor 4A, Nature: Blood Cancer Journal., e, 128 (2013), DOI:10.1038/bcj.2013.25.
  • J. S. Yadav, A. Raju, K. Ravindar And B. V. Subba Reddy, A formal stereoselective synthesis of (-)-brevisamide, Tetrahedron Lett., 54, 3227 - 3229 (2013).
  • Jhillu S. Yadav, Ande Raju, Kontham Ravindar And Basi V. Subba Reddy and Ahamad Al Khazim Al Ghamdi, The Stereoselective Total Synthesis of Putaminoxin, Synthesis., 44, 585 - 590 (2012).
  • Kontham Ravindar And Maddi Sridhar Reddy and Pierre Deslongchamps, A Highly Efficient Access to Spiroketals, Mono-unsaturated Spiroketals and Furans: Hg(II)-Catalyzed Cyclization of Alkyne Diols and Triols, Org. Lett., 13, 3178 - 3181 (2011).
  • Kontham Ravindar, Maddi Sridhar Reddy, Lisa Lindqvist And Jerry Pelletier and Pierre Deslongchamps, Synthesis of the Antiproliferative Agent Hippuristanol and Its Analogues via Suarez Cyclizations and Hg(II)-Catalyzed Spiroketalizations, J. Org. Chem., 76, 1269 - 1284 (2011).
  • Jhillu S. Yadav, K. V. Raghavendra Rao, K. Ravindar And B. V. Subba Reddy, Total Synthesis of (+)-Bourgeanic Acid Utilizing Desymmetrization Strategy, Eur. J. Org. Chem., , 58 - 61 (2011).
  • Jhillu S. Yadav, Ragam Nageshwar Rao, Begari Prem Kumar, Ragam Somaiah, Kontham Ravindar And Basi V. Subba Reddy and Ahamad Al Khazim Al Ghamdi, Concise Total Synthesis of (-)-cis-Aerangis Lactone and (-)-cis-Cognac lactone, Synthesis., 19, 3168 - 3172 (2011).
  • Ravindar Kontham and Jhillu Singh Yadav, Studies Directed Towards the Total Synthesis of Polypropionate Natural Products (–)-Ebelactone-A and (–)-Maurenone (PhD Thesis), Monograph. LAP (Lambert Academic Publishing, Germany)., ISBN: 978-3-8484-4958-3, (2011).
  • Kontham Ravindar, Maddi Sridhar Reddy, Lisa Lindqvist And Jerry Pelletier and Pierre Deslongchamps, Efficient synthetic Approach to Potent Antiproliferative Agent Hippuristanol via Hg(II)-Catalyzed Spiroketalization, Org. Lett., 12, 4420 - 4423 (2010).
  • Jhillu S. Yadav, Yerragorla Gopala Rao, Dandekar Chandrakanth And Kontham Ravindar and Basi V Subba Raddy, Total Synthesis of Aculeatins A and B from L-Malic Acid, Helvetica Chimica Acta., 93, 2426 - 2432 (2010).
  • Jhillu Singh Yadav, Dandekar Chandrakanth, Yerragorla Gopala Rao And Kontham Ravindar and Basi V. Subba Reddy, The Stereoselective Total Synthesis of (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one via Prins Cyclisation, Helvetica Chimica Acta., 93, 1432 - 1438 (2010).
  • J. S. Yadav, A. Raju, K. Ravindar And B. V. Subba Reddy, Stereoselective Total Synthesis of 11-?- and 11-?-Methoxycurvularins, Synthesis., 5, 797 - 802 (2010).
  • J. S. Yadav, K. V. Raghavendra Rao, K. Ravindar And B. V. Subba Reddy, Total Synthesis of (+)-Aculeatin D and (+)-6-epi-Aculeatin D, Synlett., 1, 51 - 54 (2010).
  • J. S. Yadav, Y. Gopala Rao, K. Ravindar, B. V. Subba Reddy And A. V. Narsaiah, Total Synthesis of Xestodecalactone C from L-Malic Acid, Synthesis., 18, 3157 - 3161 (2009).
  • J. S. Yadav, T. Srinivasa Rao, K. Ravindar And B. V. Subba Reddy, Total Synthesis of (+)-Aspicilin from D-Mannitol, Synlett., 17, 2828 - 2830 (2009).
  • J. S. Yadav, R. Somaiah, K. Ravindar And L. Chandraiah, Stereoselective total synthesis of (+)-mueggelone, a novel inhibitor of fish development, Tetrahedron Lett., 49, 2848 - 2850 (2008).
  • P. Srihari, K. Ravindar, R. Somaiah And J. S. Yadav, First Concise Total Synthesis of 5-Epi-prelactone B, Synth. Commun., 38, 1389 - 1397 (2008).
  • Jhillu S. Yadav, Basi V. S. Reddy, Ande Raju, Kontham Ravindar And Ravirala Narender, The Hydroamination of Unactivated Alkenes with Sulfonamides Catalyzed by Phosphomolybdic Acid/SiO2, Letters in Organic Chemistrystry., 5, 651 - 654 (2008).
  • J. S. Yadav, B. V. Subba Reddy, A. Raju And K. Ravindar and Gakul. Baishya, Hydrothiolation of Unactivated Alkynes Catalyzed by Indium(III) Bromide, Chemistry Letters., 36, 1474 - 1475 (2007).
  • J. S. Yadav, B. V. Subba Reddy, A. Raju And K. Ravindar and Gakul. Baishya, 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2,2,2]octane-bis(tetrafluoroborate) as Novel and Efficient Reagent for the Conjugate Addition of Indoles to ?,?-Unsaturated Ketones, Chemistry Letters., 36, 1056 - 1057 (2007).
  • J. S. Yadav, K. Ravindar And B. V. S. Reddy, A Formal Stereoselective Synthesis of (–)-Maurenone, Synlett., 12, 1957 - 1959 (2007).

Research Interest

  • Organic Chemistry

Contact Details

Dr. Ravindar Kontham

Senior Scientist,

Office: Room No 4, Entomology Building

(Opposite to Stores and Purchase Dept)

Organic Chemistry Division

CSIR-National Chemical Laboratory

Dr. Homi Bhabha Road

Pune-411008, India

Ph-Office : +91-20-2590 2301

Phone: Mobile: +91-750 788 9557

E-mail: k.ravindar@ncl.res.in

             konthamravindar@gmail.com