Santosh Kumar Jha

Santosh Kumar Jha

Physical and Materials Chemistry Division

Professional Experience

Jan 2014 – Present: Senior Scientist, CSIR-National Chemical Laboratory, Pune, India

Apr 2012 – Jan 2014:  Postdoctoral Scholar, University of California, Berkeley, USA (Advisor: Prof. Susan Marqusee)

Feb 2010 - Mar 2012: Postdoctoral Scholar, Stanford University, Stanford, USA (Advisor: Prof. Steven G. Boxer)

Oct 2003 - Nov 2009:  Ph.D., National Centre for Biological Sciences, TIFR, Bangalore, India (Advisor: Prof. Jayant B. Udgaonkar)

Selected Publications

  • Mishra P And Jha SK, An Alternatively Packed Dry Molten Globule-like Intermediate in the Native State Ensemble of a Multi-Domain Protein, J. Phys. Chem. B., 121, 9336 - 9347 (2017).
  • Acharya N, Mishra P And Jha SK, A dry molten globule-like intermediate during the base-induced unfolding of a multidomain protein, Phys. Chem. Chem. Phys., 19, 30207 - 30216 (2017).
  • Acharya N, Mishra P And Jha SK, Evidence for Dry Molten Globule-Like Domains in the pH-Induced Equilibrium Folding Intermediate of a Multi-Domain Protein, J. Phys. Chem. Lett., 7, 173 - 179 (2016).
  • Jha SK And Marqusee S, Kinetic evidence for a two-stage mechanism of protein denaturation by guanidinium chloride, Proc. Natl. Acad. Sci. USA., 111, 4856 - 4861 (2014).
    Recommended by Faculty of 1000 Biology http://f1000.com/prime/718313266
  • Jha SK, Ji M, Gaffney KJ And Boxer SG, Direct measurement of the protein response to an electrostatic perturbation that mimics the catalytic cycle in ketosteroid isomerase, Proc. Natl. Acad. Sci. USA., 108, 16612 - 16617 (2011).
  • Jha SK And Udgaonkar JB, Direct evidence for a dry molten globule intermediate during the unfolding of a small protein, Proc. Natl. Acad. Sci. USA., 106, 12289 - 12294 (2009), DOI:(Recommended by Faculty of 1000 Biology http://f1000.com/14021991).
    Recommended by Faculty of 1000 Biology http://f1000.com/14021991
  • Jha SK, Dhar D, Krishnamoorthy G And Udgaonkar JB , Continuous dissolution of structure during the unfolding of a small protein, Proc. Natl. Acad. Sci. USA., 106, 11113 - 11118 (2009).
  • Jha SK And Udgaonkar JB , Exploring the cooperativity of the fast folding reaction of a small protein using pulsed thiol labeling and mass spectrometry, J. Biol. Chem., 282, 37479 - 37491 (2007).

Research Interest

  • Structural Biology
  • Chemical Biology
  • Physical Chemistry
  • Laser spectroscopy & Instrumentation
  • Spectroscopy
  • Human Diseases
  • Kinetics analysis of Chemical Reactions
  • Protein Chemistry and Proteomics
  • Biological Mass Spectrometry
  • Biophysical Science

Contact Details

Dr. Santosh Kumar Jha
Senior Scientist
Physical and Materials Chemistry Division
Office: F - 101, Polymer and Advanced Materials Laboratory
CSIR - National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411008, India

Phone: +91-20-25902588
Fax: +91-20-25902615
E-mail: sk.jha@ncl.res.in