Organo metallic chemistry

Organo transition metal chemistry

  • gano transition metal chemistry is the chemistry of the d-block transition metals. Many and remarkable reactions take place only in the presence of transition metal complexes. Several enzymatic systems also contain transition metals and thus the organo transition metal catalysis seeks to mimic these natural catalytic systems. Organometallic chemistry involves the interaction of an organic compound with a transition metal species to form an intermediate compound whose reactions differ from the typical organic molecules and thus provide new synthetic pathways and methodologies to the organic chemist.
  • Co-ordination of an organic moiety to a transition metal remarkably alters the properties of the compound so as to undergo completely different types of reactions from the free molecule which is the area of research world wide. The study involves stoichiometric as well as catalytic use of transition metal complexes in various organic reactions and lends itself to Green Technology and environmentally clean process alternatives to existing traditional and polluting organic manufacturing processes.


  • Nitrogen ligands: The transition metal catalyzed reactions of aryl halides with olefins (Mizoroki-Heck), phenyl boronic acid (Suzuki coupling) and Buchwald-Hartwig) amination, new catalysts and effect of c-catalysts - Aryl halide activation - Part I. Suresh Iyer, Girish M. Kulkarni, C. Ramesh, Aruna K. Sattar, Ind. J. Chem., 2005, 44B (9), 1894.

Aryl - Vinyl halide Activation

  • Aryl and vinyl halides are ubiquitous molecules in organic chemistry and their displacement reactions a source of various building blocks in organic synthesis. The transition metal activation of halides is thus an exciting area of organometallic catalysis as well as stoichiometric reactions which principles has been rigorously studied. There are still ample opportunities for the design and study of nitrogen and other ligands and transition metal catalysis. C - H activation is the next step in the activation of organic molecules towards their functionalization and thus alternative and abundant raw material source in organic synthesis and thus unfunctionalized organic molecules can be used as raw materials in organic synthesis of natural products or essential drug molecules


  • Nitrogen ligands: The transition metal catalyzed reaction of aryl halides with olefins (Mizoroki-Heck), phenyl boronic acid (Suzuki coupling) and (Buchwald-Hartwig) amination, new catalysts and effect of co-catalysts – Aryl halides activation – Part I. Iyer, S.; Kulkarni, G. M.; Ramesh, C.; Sattar, A. K. Ind. J. Chem., 2005, (9), 1894

Catalytic Transfer Hydrogenation

Racemic Catalysis - Chiral Amplification

  • Metal catalyzed transfer hydrogenation is convenient in large scale synthesis since there is no need to employ a high Hydrogen pressure or to use expensive hazardous reducing agents. Raney Ni is very common catalysts in these reductions and suffers from the fact of its pyrophoric nature. An alternative are the several non hazardous and safe to handle homogeneous Ni. Pd and Ru catalysts which can also be easily prepared in the laboratory. These catalysts are further amenable to asymmetric induction by easy manipulation of various chiral ligands. Chiral amplification, where tiny quantities of one enantiomer can be used can be studied in these transfer hydrogenations and expected to give high enantioselection.


  • NiCl2(PPh3)2 catalysed transfer hydrogenation of ketones and aldehydes by propan-2-ol. Suresh Iyer; Jos P. Varghese J. Chem. Soc., Chem. Commun., 1995, 465..
  • Ni{P(OC6H5)3}4 catalyzed transfer hydrogenation using HCOONH4. Iyer, S.; Sattar, A. K, Synth. Commun., 1998, 28 (10), 1721 - 1725.