Research Group Publications
 
  • Bhoite A, Gaur NK, Palange M, Kontham R, Gupta V And Kulkarni K, Structure of epoxide hydrolase 2 from Mangifera indica throws light on the substrate specificity determinants of plant epoxide hydrolases, Biochem Biophys Res Commun., 733, 150444 (2024), DOI:10.1016/j.bbrc.2024.150444.
  • Omble A, Mahajan S, Bhoite A And Kulkarni K*, Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF, Commun Biol., 7, 543 (2024), DOI:10.1038/s42003-024-06194-6.
  • Gaur NK, Urankar S, Sengupta D, Chepuri VR, Makde RD And Kulkarni K*, A cell based assay using virus-like particles to screen AM type mimics for SARS-CoV-2 neutralisation, Biochem Biophys Res Commun., 718, 150082 (2024), DOI:10.1016/j.bbrc.2024.150082.
  • Motiwala Z, Sandholu AS, Sengupta D And Kulkarni K*, Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily, iScience., 26, 107031 (2023), DOI:10.1016/j.isci.2023.107031.
  • Vasudevan N, Motiwala Z, Ramesh R, Wagh SB, Shingare RD, Katte R, Anand A, Choudhary S, Kumar A, Gokhale RS, Kulkarni KA* And Reddy DS* (*Corrosponding authors), Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors: An effective strategy towards development of potent anti-tubercular agents, Eur J Med Chem., 259, 115633 (2023), DOI:10.1016/j.ejmech.2023.115633.
  • Suri K, Rajput N, Sharma P, Omble AD, Kulkarni K And Gahlay GK, In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility, Front Cell Dev Biol., 11, 1151672 (2023), DOI:10.3389/fcell.2023.1151672.
  • Ammu Suresh, Balaji Prakash* And Kiran Kulkarnia* (*Corrosponding authors), Characterizing a novel CMK-EngA fusion protein from Bifidobacterium: Implications for inter-domain regulation, Bio Biochem Biophys Rep., 33, 101410 (2023), DOI:10.1016/j.bbrep.2022.101410.
  • Gaur NK, Ghosh B, Goyal VD*, Kulkarni K* And Makde RD* (*Corrosponding authors), Evolutionary conservation of protein dynamics: insights from all-atom molecular dynamics simulations of ‘peptidase’ domain of Spt16, J Biomol Struct Dyn ., 41, 1445 - 1457 (2023), DOI:10.1080/07391102.2021.2021990.
  • Roy D, Sengupta D And Kulkarni K*, Substrate induced dynamical remodeling of the binding pocket generates GTPase specificity in DOCK family of guanine nucleotide exchange factors, Biochem Biophys Res Commun., 631, 32 - 40 (2022), DOI:10.1016/j.bbrc.2022.09.059.
  • Kalshetti RG, Rajput R, Motiwala Z, Srinivasa Reddy D*, Kulkarni KA* And Ramana CV* (*Corrosponding authors), Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins, Bioorg Med Chem Lett., 77, 129722 (2022), DOI:10.1016/j.bmcl.2022.129022.
  • Aishwarya Omble And Kiran Kulkarni*, GPCRs that Rhoar the Guanine nucleotide exchange factors, Small GTPases., 13, 84 - 99 (2022), DOI:10.1080/21541248.2021.1896963.
  • Gaur NK, Goyal VD, Kulkarni K And Makde RD., Machine learning classifiers aid virtual screening for efficient design of mini-protein therapeutics, Bioorg Med Chem Lett., 38, 127852 (2021), DOI:10.1016/j.bmcl.2021.127852.
  • Thomas Pucadyil*, Kiran Kulkarni* And Durba Sengupta* (*Corrosponding authors), Molecular Interplay at the Membrane and Impact on Cellular Physiology, J Membr Biol., 254, 239 - 242 (2021), DOI:10.1007/s00232-021-00183-0.
  • Motiwala Z, Darne P, Prabhune A, Inamdar MS And Kulkarni K*(*Corrospoding author), Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein, J Membr Biol., 254, 65 - 74 (2021), DOI:10.1007/s00232-020-00166-7.
  • Sneha Singh, Hirekodathakallu V. Thulasiram*, Durba Sengupta And Kiran Kulkarni* (* Corrosponding authors), Dynamic coupling analysis on plant sesquiterpene synthases provides leads for the identification of product specificity determinants, Biochem Biophys Res Commun ., 536, 107 - 114 (2021), DOI:10.1016/j.bbrc.2020.12.041.
  • Anand S. Sandholu, Sharmila P. Mujawar, Krithika Ramakrishnan, Hirekodathakallu V. Thulasiram And Kiran Kulkarni* (*Corrosponding author), Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus, Proteins., , 1 - 10 (2020), DOI:10.1002/prot.25891.
  • Paresh R. Athawale, Hanuman P. Kalmode, Zenia Motiwala, Kiran A. Kulkarni And * D. Srinivasa Reddy* (* Corrosponding authors), Overturning the Peribysin Family Natural Products Isolated from Periconia byssoides OUPS-N133: Synthesis and Stereochemical Revision of Peribysins A, B, C, F, and G, Org. Lett., 22, 3104 - 3109 (2020), DOI:10.1021/acs.orglett.0c00857.
  • Nidhi S. Saikhedkar, Rakesh S. Joshi, Ashiwini S. Bhoite, Radhika Mohandasan, Amit Kumar Yadav, Moneesha Fernandes, Kiran A. Kulkarni* And Ashok P. Giri* (Corrosponding authors), Tripeptides derived from reactive centre loop of potato type II protease inhibitors preferentially inhibit midgut proteases of Helicoverpa armigera, Insect Biochem. & Mol. Biol., 95, 17 - 25 (2018), DOI:https://doi.org/10.1016/j.ibmb.2018.02.001.
  • Hanuman P. Kalmode, Kishor L. Handore, Raveena Rajput, Samir R. Shaikh, Rajesh G. Gonnade, Kiran A. Kulkarni* And D. Srinivasa Reddy* (*Corrospoding authors), Total Synthesis and Biological Evaluation of Cell Adhesion Inhibitors Peribysin A and B: Structural Revision of Peribysin B, Org. Lett., 20, 7003 - 7006 (2018), DOI:10.1021/acs.orglett.8b02838.
  • Anand S. Sandholu, Madhura Mohole, William L. Duax, Hirekodathakallu V. Thulasiram, Durba Sengupta And Kiran Kulkarni*, Dynamics of loops at the substrate entry channel determine the specificity of iridoid synthases, FEBS Letters., 592, 2624 - 2635 (2018), DOI:10.1002/1873-3468.13174.
  • Amit Kumawat, Suman Chakrabarty* And Kiran Kulkarni*, Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions, Sci. Reports., 7:45829, 1 - 11 (2017), DOI:10.1038/srep45829.
  • Nora B. Cronin, Jing Yang, Ziguo Zhang, Kiran Kulkarni, Leifu Chang, Hiroyuki Yamano And David Barford, Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain, J. Mol. Biol., 427, 3300 - 3315 (2015), DOI:dx.doi.org/10.1016/j.jmb.2015.08.023.
  • Ioannis Manolaridis*, Kiran Kulkarni*, Roger B. Dodd, Satoshi Ogasawara, Ziguo Zhang, Ganka Bienva, Nicola O’ Reilly, Sarah J. Hanrahan, Andrew J. Thompson, Nora Cronin And So Iwata and David Barford. (* Equal first author), Mechanism of prenylated CAAX protein processing by the integral membrane protease Rce1, Nature., 504, 301 - 305 (2013), DOI:10.1038/nature12754.
  • Zhang Z, Yang J, Cronin N, Kulkarni K* And Barford D* (* Corresponding authors), The four canonical TPR subunits of human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelixexhibit a conserved mode of dimerisation, J. Mol. Biol., 425, 4236 - 4248 (2013), DOI:dx.doi.org/10.1016/j.jmb.2013.04.004.
  • K. Kulkarni, Z. Zhang, L. Chang, J. Yang, P. C. A. da Fonseca And D. Barford , Building a pseudo- atomic model of the anaphase-promoting complex, Acta Crystallogr D Biol Crystallogr., D69, 2236 - 2243 (2013), DOI:10.1107/S0907444913018593.
  • William C.H. Chao*, Kiran Kulkarni*, Ziguo Zhang, Eric H. Kong And David Barford (* Equal first author), Structure of the mitotic checkpoint complex, Nature., 484, 208 - 213 (2012), DOI:10.1038/nature10896.
  • Jun He*, Kiran Kulkarni*, Paula C.A. da Fonseca, Dasha Krutauz, Michael H. Glickman, David Barford And Edward P. Morris (* Equal first authors), The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as closed toroid of two concentric ?-helical rings, Structure., 20, 513 - 521 (2012), DOI:10.1016/j.molcel.2011.10.020.
  • Kulkarni K, Yang J, Zhang Z And Barford D. , Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors, J. Biol. Chem., 286, 25341 - 25351 (2011), DOI:10.1074/jbc.M111.236455.
  • Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger B. Dodd, Corine Mas-Droux And David Barford , Crystal structure of ICMT reveals the mechanism of CAAX motif postprenyl modification by an integral membrane carboxyl methyltransferase, Mol. Cell., 44, 997 - 1004 (2011), DOI:10.1016/j.molcel.2011.10.020.
  • Thamotharan S, Karthikeyan T, Kulkarni KA, Shetty KN, Surolia A, Vijayan M And Suguna K. , Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin, Acta Crystallogr D Biol Crystallogr., D67, 218 - 227 (2011), DOI:10.1107/S0907444911004525.
  • Zhang Z, Kulkarni K, Hanrahan SJ, Thompson AJ And Barford D, The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27, EMBOJ., 29, 3733 - 3744 (2010), DOI:10.1038/ emboj.2010.247.
  • Kulkarni KA, Katiyar S, Surolia A, Vijayan M And Suguna K, Structure and sugar-specificity of basic winged-bean lectin: structures of new disaccharide complexes and a comparative study with other known disaccharide complexes of the lectin, Acta Crystallogr D Biol Crystallogr., D64, 730 - 737 (2008), DOI:10.1107/S0907444908011323.
  • Kulkarni KA, Katiyar S, Surolia A, Vijayan M And Suguna K, Crystal structure of basic winged bean lectin complexed with alpha Gal containing disaccharide with different linkages, Acta Crystallogr D Biol Crystallogr., D64, 730 - 737 (2008), DOI:10.1107/S0907444908011323.
  • Kulkarni KA, Katiyar S, Surolia A, Vijayan M And Suguna K, Generation of blood group specificity: New insights from structural studies on the complexes of A – and B – reactive saccharides with basic winged bean agglutinin, Proteins., 68, 762 - 769 (2007), DOI:10.1002/prot.21428.
  • Kulkarni KA, Katiyar S, Surolia A, Vijayan M And Suguna K, Structural basis for the carbohydrate-specificity of basic winged-bean lectin and its differential affinity for Gal and GalNAc, Acta Crystallogr D Biol Crystallogr., 62, 1319 - 1324 (2006), DOI:10.1107/S0907444906028198.
  • Latha VL*, Kulkarni KA*, Rao RN, Kumar NS And Suguna K (*Equal First authors), Crystallization and preliminary X-ray crystallographic analysis of a galactose-specific lectin from Dolichos lablab, Acta Crystallograph Sect F Struct Biol Cryst Commun., 62, 163 - 165 (2006), DOI:10.1107/S1744309106001448.
  • Kiran A. Kulkarni, Sharmistha Sinha, Samiksha Katiyar, Avadhesha Surolia, Mamannamana Vijayan And Kaza Suguna*, Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: a crystallographic, thermodynamic and modelling study, FEBS Lett., 19, 6775 - 6780 (2005), DOI:10.1016/j.febslet.2005.11.011.
  • K. A. Kulkarni, A. Srivastava, N. Mitra, N. Sharon, A. Surolia, M. Vijayan* And and K. Suguna*, Effect of Glycosylation on the Structure of Erythrina corallodendron Lectin, PROTEINS: Structure, Function, and Bioinformatics., 56, 821 - 827 (2004), DOI:10.1002/prot.20168.