Research Interest:

  • Synthetic and mechanistic / bio-organic chemistry related to cyclitols; neighboring group effects; organic reactions in the solid state.

Professional Experience

  • 1992-todate- Scientist - National Chemical Laboratory, Pune.
  • 1987-1991- Post Doctoral Research Associate- University of Oregon, Eugene, OR, USA
  • 1987- Ph.D (Organic Chemistry) - Indian Institute of Science, Bangalore

Selected Publications

  • Elaboration of the ether cleaving ability and selectivity of the classical Pearlman’s catalyst [Pd(OH)2/C]: Concise synthesis of a precursor for a myo- inositol pyrophosphate. Alson Mart; M. S. Shashidhar. Tetrahedron, 2012, 68, In press.
  • Synthesis of the aminocyclitol units of (–) hygromycin A and methoxyhygromycin from myo-inositol. B. P. Gurale, M. S. Shashidhar, R. G. Gonnade. J. Org. Chem. 2012, 77, 5801−5807
  • Solvent induced crystallization of 1,2,3,4(6),5-penta-O-acetyl-6(4)-O-[(1S)-10-camphor sulfonyl]-myo-inositol diastereomers associated via weak trifurcated C–H×××O interactions. K. Manoj, R. G. Gonnade, M. S. Shashidhar, M. M. Bhadbhade. CrystEngComm, 2012, 14, 1716 – 1722
  • Thermal epimerization of inositol 1,3-benzylidene acetals in the molten state. B. P. Gurale, S. Krishnaswamy, K. Vanka and M. S. Shashidhar. Tetrahedron, 2011, 67, 7280-7288.
  • Intermolecular benzoyl group transfer reactivity in crystals of racemic 2,6-di-O-benzoyl-myo-inositol 1,3,5-orthobenzoate: controlling reactivity by solvate (pseudopolymorph) formation. S. Krishnaswamy, M. S. Shashidhar, M. M. Bhadbhade. CrystEngComm, 2011, 13, 3258-3264.
  • Orthogonally protected cyclohexane hexols by ‘one reaction – one product’ approach: efficient access to cyclitols and their derivatives. R. C. Jagdhane and M. S. Shashidhar. Eur. J. Org. Chem. 2010, 2945-2953.
  •  Enhancing intermolecular benzoyl-transfer reactivity in crystals by growing a “reactive” metastable polymorph by using a chiral additive. C. Murali, M. S. Shashidhar, R. G. Gonnade, M. M. Bhadbhade. Chem. Eur. J. 2009, 15, 261-269.
  •  Inositol derived crown ethers: effect of auxiliary protecting groups and the relative orientation of crown ether oxygen atoms on their metal ion binding ability. S. S. Dixit, M. S. Shashidhar. Tetrahedron, 2008, 64, 2160-2171.
  • Concomitant dimorphs of tri-O-[p-halobenzoyl]-myo-inositol 1,3,5-orthoformates with different halogen bonding contacts: first order crystal-to-crystal thermal phase transition of kinetic form to the thermodynamic form. R. G. Gonnade, M. M. Bhadbhade, M. S. Shashidhar, A. K. Sanki. Chem. Commun. 2005, 5870-5872.
  • Short S=O…C=O contacts associate diastereomers of 2,4(6)-di-O-benzoyl-6(4)-O-[(1S)-10-camphorsulfonyl]-myo-inositol 1,3,5-orthoformate in their inclusion complexes. K. Manoj, K. M. Sureshan, R. G. Gonnade, M. M. Bhadbhade, M. S. Shashidhar. Cryst. Growth. Design, 2005, 5, 833-836.
  • Regioselective protection and deprotection of inositol hydroxyl groups. K. M. Sureshan, M. S. Shashidhar, T. Praveen, T. Das. Chem. Rev. 2003, 103, 4477-4503.
  • Reactivity controlled by lattice interactions in crystal: Intermolecular acyl transfer in (±)-2,4-di-O-benzoyl-myo-inositol 1,3,5-orthoformate. T. Praveen, U. Samanta, T. Das, M. S. Shashidhar, P. Chakrabarti. J. Am. Chem. Soc. 1998, 120, 3842-3845.