Dye Sensitised Solar Cells

  • Synthesis of new molecules and their application towads Dye Sensitised Solar Cells.
  • Reference: 1. Magdalena Marszalek, Satyawan Nagane, Amol Ichake, Robin Humphry-Baker, Vincent Paul,* Shaik M. Zakeeruddin* and Michael Gratzel*. “Tuning spectral properties of phenothiazine based donor–p–acceptor dyes for efficient dye-sensitized solar cells”, Journal of Materials Chemistry, 2012, 22, 889-894.

Synthesis of biologically active molecules

  • Synthesis of molecules/drugs by better alternative non-infingent routes.
  • Reference: 1. Atul R. Gholap, Vincent Paul and Kumar V. Srinivasan. “A Novel Process for the synthesis of class I antiarrhythmic agent (±) Cibenzoline and its analogues”, Synthetic Communications, 2008, 38, 2025-2036.

Ionic Liquids

  • Synthesis of ionic liquids and their applications to various organic transformation reactions.
  • Reference: 1. Borikar, S. P.; Daniel, T.; Paul V. “A mild, efficient and regioselective monobromination of arylamines and phenols using [BBIm]Br3 as a new reagent”, Synthetic Communications, 2010, 40, 647-653.
  • 2. Sanjay P. Borikar, Thomas Daniel, Vincent Paul. “An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions”, Tetrahedron Letters, 2009, 50, 1007-1009.

Total Synthesis

  • First total synthesi of molecules of biological interes.
  • Reference: 1. Sanjay P. Borikar, Vincent Paul, Vedavati G. Puranik, Vilas T. Sathe, Selene Lagunas-Rivera, Mario Ordónez, “First Total Synthesis of 5-Hydroxy-3-methyl-4-propylsulfanyl-5H-furan-2-one: A Cancer Chemopreventive Agent”, Synthesis, 2011, 10, 1595-1598.

Carbohydrate Chemistry

  • Synthesis of nucleosides and their activity against HIV, HBV.
  • Reference: 1. Song, G.Y.; Paul, V.; Choo, H.; Morrey, J.; Sidwell, R.W.; Schinazi, R. F.; and Chu, C.K. “Enantiomeric Synthesis of D- and L-Cyclopentenyl Nucleosides and their Antiviral Activity Against HIV and West Nile Virus”, J. Med. Chem., 2001, 44, 3985-3993).

Process Chemistry

  • Development of Non-infringing routes for the synthesis of drugs/API/molecules.
  • Synthesis and process development of Anti-tumor drug Cilastatine.
  • Synthesis of anti-tumor drug Capecitabine.
  • Synthesis and process development of Dorzolamide for glaucoma.
  • Synthesis of anti-HIV drug Tenofovir.
  • New method for resolution of Ondansetron anti-emetic drug.
  • Process development of Rivastigmine for Alzheimer disease.
  •  Process development of antibiotic drug Roflumilast.
  • Process development for Anti-Malarial drug Benflumetol.