Research Interest:

  • Molecular Parasitology Comparative genomics
  • Biochemistry
  • Cell Biology
  • Metabolomics
  • Comparative genomics

Professional Experience

  • 2012 - Current -  Scientist, CSIR-National Chemical Laboratory, Pune, India
  • 2004-2011 - Post Doctoral Research Fellow (Advisor : Prof. David S. Roos, University of Pennsylvania, Philadelphia, USA.
  • 1997-2004 - Ph.D. Student (Advisor : Prof. G. Padmanaban, Indian Institute of Science, Bangalore, India)

Selected Publications

  • Reid J. A, Vermont J. S, Cotton A. J, Harris D, Hill-Cawthorne A. G, Könen-Waisman S, Latham S, Mourier T, Norton R, Quail A. M, Sanders M, Shanmugam D, Sohal A, Wasmuth D. J, Brunk P. B, Grigg E. M, Howard C. J, Parkinson J, Roos S. D, Trees J. T, Berriman M, Pain A & Wastling M. J. Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. (2012). PLOS Pathogens. 8(3):e1002567.
  • Magarinos MP, Carmona SJ, Crowther GJ, Ralph SA, Roos DS, Shanmugam D, Van Voorhis WC, Aguero F. TDR Targets: a chemogenomics resource for neglected diseases. (2012). Nuc. Acid Res. 40:D1118-27.
  • Shanmugam D, Ralph SA, Carmona SJ, Crowther GJ, Roos DS and Fernán Agüero F. Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets. (2012). In Press – Wiley Book Series (Vol 4) on “Drug Discovery in Infectious Diseases” titled Chemo- and Immuno-therapeutic advances for treatment and control of helminthic infections.
  • Coyne S. R, Hannick L, Shanmugam D, Hostetler B. J, Brami D, Joardar S. V, Johnson J, Radune D, Singh I, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather W. M, Vaidya B. A, Wilkes E. D, Rajagopalan V, Asai J. D, Pearson G. C, Findly C. R, Dickerson W. H, Badger J, Wu M, Martens C, Van de Peer Y, Roos S. D, Cassidy- Hanley M. D and Clark G. T. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free- living relatives and a host species: insights into adoption of a parasitic lifestyle and prospects for disease control. (2011). Genome Biology. 12:R100.
  • Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart L, Myler P, and Roos DS. Crystal structure of Toxoplasma gondii Porphobilinogen synthase: Insights on octameric structure and porphobilinogen formation. (2011). J. Biol. Chem. 286(17): 15298-307.
  • Crowther GJ, Shanmugam D, Carmona SJ, Doyle MA, Hertz-Fowler C, Berriman M, Nwaka S, Ralph SA, Roos DS, Van Voorhis WC and Aguero F. Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. (2010). PLOS Neglected Tropical Diseases. 4(8):e804. Doi:10.1371 /journal.pntd.0000804.
  • Shanmugam D, Wu B, Ursula Ramirez, Jaffe E and Roos DS. Plastid associated porphobilinogen synthase from Toxoplasma gondii: Kinetic and structural properties validate therapeutic potential. (2010). J. Biol. Chem. 285(29): 22122-31.
  • Aguero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Chan AWE, Chen F, Crowther GJ, Hertz-Fowler C, Hopkins AL, McAllister G, Nwaka S, Overington JP, Pain A, Paolini GV, Pieper U, Ralph SA, Riechers A, Roos DS, Sali A, Shanmugam D, Suzuki T, Van Voorhis WC, Verlinde CL. Genomic-scale Prioritization of Drug Targets: the TDR Targets database. (2008). Nat. Rev. Drug Discov. 7, 900- 907.
  • Bonday, Z.Q.*, Dhanasekaran, S.*, Rangarajan, P.N., Padmanaban, G. Import of host δ-aminolevulinate dehydratase into the malarial parasite: Identification of a new drug target. (2000). Nature Med. 6(8), 898-903. * ZQB and SD made equal contributions to this study.