Research Group Publications

 
  • Hariharakrishnan Chidambaram And Rashmi Das and Subashchandrabose Chinnathambi*, G-Protein coupled Purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodelling in microglia, Under Review., , (2022).
  • Rashmi Das and Subashchandrabose Chinnathambi*. , Microglia modulate the podosome rearrangements in lamella in response to external Tau aggregates, Under Review., , (2022).
  • Rashmi Das and Subashchandrabose Chinnathambi*. , Microglia degrade extracellular Tau oligomers deposit via Purinergic P2Y12-driven podosome formation, Under Review., , (2022).
  • Smita Eknath Desale and Subashchandrabose Chinnathambi*, Alpha-Linolenic acid-induced podosome formation and spontaneous higher-order assemblies in N9 microglia cell for chemotaxis, Cellular Signaling., , (2022), DOI:Revision.
  • Tazeen Qureshi and Subashchandrabose Chinnathambi*. , Histone Deacetylase-6 modulates Tau Function in Alzheimer’s Disease, Preparation., , (2022).
  • Abhishek A Balmik and Subashchandrabose Chinnathambi*., Inter-relationship of Histone Deacetylase-6 with cytoskeletal organization and remodeling, European Journal of Cell Biology., , (2022).
  • Tushar Dubey #, Shweta Sonawane#, M K Chaitanya Mannava And AshwiniKumar Nangia and Subashchandrabose Chinnathambi*, Curcumin-Pyrogallol and their cocrystal restore nuclear transport and reduce Tau phosphorylation in Alzheimer’s disease, Under Revision., , (2022).
  • Shweta K Sonawane And Tushar Dubey and Subashchandrabose Chinnathambi*. , Tau and Alzheimer’s disease, Royal Chemical Society, Drug Discovery., , (2022).
  • Rashmi Das&, Abhishek A Balmik& And Shweta K Sonawane and Subashchandrabose Chinnathambi*. , Soluble aggregation species of A? and Tau and their role in Alzheimer’s disease, Royal Chemical Society, Drug Discovery., , (2022).
  • Shweta Kishor Sonawane1, 2, Anshu Raina3, Amitabha Majumdar3 Subashchandrabose Chinnathambi 1, 2 And *, EGCG modulates nuclear formaldehyde-induced Tau phosphorylation in Neuronal cells, Under Review., , (2022).
  • Tushar Dubey 1, 5, H. V. Thulasiram6, 7, Subashchandrabose Chinnathambi 1, 7 And *, Bacopa monnieri modulate Tau phosphorylation and impaired nuclear transport, Under Revision., , (2022).
  • Tushar Dubey, Preeti Kushwaha, H. V. Thulasiram, Anshu Raina, Amitabha Majumdar And Subashchandrabose Chinnathambi*. , Tau aggregation and Tau toxicity modulated by Ayurvedic extract of Brahmi, Under Review., , (2022).
  • Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*. , Dual modifications of Tau do not enhance aggregation, Under Review., , (2022).
  • 18. Pramod G. Nagaraju, P Sindhu, Tushar Dubey, Subashchandrabose Chinnathambi, Pooja J Rao And Poornima Priyadarshini C G*. , Influence of protein, polysaccharide and Maillard conjugate on the stability, in vitro release, anti-oxidant property and cell viability of eugenol-olive oil nanoemulsions, International Journal of Biological Macromolecules., , (2021).
  • 17. Subashchandrabose Chinnathambi* and Nalini Vijay Gorantla. , Implications of Valosin-containing protein in promoting autophagy to prevent Tau aggregation in Alzheimer’s disease, Neuroscience., , (2021).
  • Sonawane SK And Uversky VN and Subashchandrabose Chinnathambi*. , Baicalein inhibits heparin-induced Tau aggregation by initializing Tau oligomer formation in vitro, Cell Communication & Signaling., , (2021).
  • Rashmi Das and Subashchandrabose Chinnathambi*. , Microglial remodeling of actin network by Tau oligomers, via G protein- coupled Purinergic receptor, P2Y12R-driven chemotaxis, Traffic., Feb 2021, (2021), DOI:https://doi.org/10.1111/tra.12784.
  • Smita Eknath Desale And Subashchandrabose Chinnathambi*. , ?-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia, Biomolecular Medicine., (2021) 2:4, (2021), DOI:https://doi.org/10.1186/s43556-021-00028-1.
  • Smita Eknath Desale And Subashchandrabose Chinnathambi*., Alpha-Linoleanic acid modulates phagocytosis of extracellular Tau and induces microglial migration. Dec;15(1):84-100. doi: 10.1080/19336918.2021.1898727, Cell Adhesion & Migration., , (2021), DOI:Revision.
  • Smita Eknath Desale And Subashchandrabose Chinnathambi*, Phosphoinositides Signaling Modulates Microglial Phagocytosis in Alzheimer’s disease, Cell Communication & Signaling., , (2021), DOI:Press.
  • Abhishek A Balmik and Subashchandrabose Chinnathambi*., Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease, Cell Communication & Signaling., , (2021), DOI:Revision.
  • Tushar Dubey and Subashchandrabose Chinnathambi*. , Photodynamic sensitizers modulate Cytoskeleton structural dynamics in cells, Cytoskeleton., , (2021), DOI:Revision.
  • Smita Eknath Desale#, Hariharakrishnan Chidambaram# And and Subashchandrabose Chinnathambi*, G-protein coupled receptor, PI3K and Rho Signaling pathways regulates the cascades of Tau and Amyloid-? in Alzheimer’s disease, Molecular Biomedicine., , (2021), DOI:Accepted.
  • Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*, Baicalein inhibits heparin-induced Tau aggregation by initializing Tau oligomer formation in vitro, Cell Communication & Signaling., , (2021), DOI:Cell Communication & Signaling.
  • Tushar Dubey And Subashchandrabose Chinnathambi*, Heat Stress Modulates the GSK-3? Levels and Tau Phosphorylation, Under Review., , (2021).
  • Tushar Dubey, Shweta Kishor Sonawane, Benchamin Abraham, MK Chaitanya Mannava, Ashwini K. Nangia And Subashchandrabose Chinnathambi*, The Curcumin-Artemisinin co-amorphous inhibits Tau aggregation and rescues Tau toxicity, Under Review., , (2021), DOI:Review.
  • Tushar Dubey and Subashchandrabose Chinnathambi*., P10 is a New Ray of Hope for Alzheimer’s disease: A Hypothesis, Under Review., , (2021), DOI:Review.
  • Tushar Dubey, Nalini Vijay Gorantla And Subashchandrabose Chinnathambi*, Photo-excited Toluidine Blue disaggregates the Repeat Tau and modulates Cytoskeletal structure in neuronal cells, Under Review., , (2021).
  • Shweta Kishor Sonawane, Nalini Vijay Gorantla, Abha Dangi And Udaya Kiran Marelli* and Subashchandrabose Chinnathambi*. , Polyamines inhibit Tau aggregation in vitro and influence the cell death pathways in neuronal cells, Under Revision., , (2020).
  • Rashmi Das# And Abhishek Ankur Balmik# and Subashchandrabose Chinnathambi*. , Melatonin mediates anti-inflammatory microglial phenotypes and reduces Tau phosphorylation via Nrf2 activation, ASN Neuro., , (2020), DOI:Press.
  • Dubey T, Gorantla NV, Chandrasekhara K T And Subashchandrabose Chinnathambi*. , Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates Cytoskeletal network in neuronal cells, Scientific Reports, Nature Group., Jul 23;10(1):12380, (2020), DOI:doi: 10.1038/s41598-020-69403-2.
  • Abhishek Ankur Balmik, Hariharakrishnan, Abha Dangi And Udayakiran Marelli and Subashchandrabose Chinnathambi*. , HDAC6 ZnF UBP as the modifier of Tau structure and function, ACS Biochemistry., 2020, (2020), DOI:doi: 10.1021/acs.biochem.0c00585.
  • Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. , Chemokine receptor, CX3CR1 interaction and signalling in neuronal and microglial cells during Tauopathy, Cell & Bioscience., Sep 15;10:109, (2020), DOI:10.1186/s13578-020-00474-4.
  • Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. , Role of Cysteine in Tau filament formation, Journal of Biomolecular Structure Dynamics., , (2020), DOI:Press.
  • Rashmi Das and Subashchandrabose Chinnathambi*. , Actin-mediated microglial chemotaxis via Purinergic receptor in Alzheimer's disease, Neuroscience., Nov 10;448:, 325 - 336 (2020), DOI:doi: 10.1016/j.neuroscience.2020.09.024.
    Cover Art Proposal Submitted
  • Shwetha Nanjundaiah, Hariharakrishnan Chidambaram, Madhura Chandrashekar And Subashchandrabose Chinnathambi*, Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease, Cellular and Molecular Neurobiology., , (2020), DOI:10.1007/s10571-020-00883-6.
  • COVER PAGE: Gorantla Nalini, Sunny Lisni, Rajasekhar Kolla, Nagaraju, Pramod; CG Poornima, Govindaraju Thimmaiah And Subashchandrabose Chinnathambi*., Amyloid-beta-derived Peptidomimetics inhibits Tau aggregation, ACS Omega., , (2020), DOI:Accepted.
  • Madhura Chandrashekar and Subashchandrabose Chinnathambi*., Protein Misfolding and Aggregation in Neurodegenerative Disease, Advances in Bioengineering., , (2020).
  • Nalini Vijay and Subashchandrabose Chinnathambi*., Autophagic pathways to clear the Tau aggregates in Alzheimer’s disease, Cellular and Molecular Neurobiology., , (2020), DOI:10.1007/s10571-020-00897-0.
  • Abha Dangi||, Abhishek Ankur Balmik||, Archana Ghorpade||, Nalini Vijay Gorantla$, Shweta Kishor Sonwane$, Subashchandrabose Chinnathambi* And Udaya Kiran Marelli*, Residue-based propensity of aggregation in Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6, RSC Advances., , (2020), DOI:https://doi.org/10.1039/D0RA03809A.
  • Shweta Kishor Sonawane* and Subashchandrabose Chinnathambi*. , P301L, FTDP-17 mutant exhibits enhanced glycation in vitro, Journal of Alzheimer's Disease., , (2020), DOI:10.3233/JAD-191348.
  • Rashmi Das And Abhishek Ankur Balmik and Subashchandrabose Chinnathambi*. , Phagocytosis of full-length Tau oligomers by Actin-remodeling of Activated Microglia, Journal of Neuroinflammation., , (2020), DOI:doi: 10.1186/s12974-019-1694-y.
  • Shweta Kishor Sonawane, Chidambaram H, Boral D, Gorantla NV, Balmik AA, Dangi A, Ramasamy S, Marelli UK And Subashchandrabose Chinnathambi*., EGCG impedes human Tau aggregation and interacts with Tau, Nature Scientific Reports Accepted., , (2020), DOI:Revision.
  • Gorantla NV, Das R, Chidambaram H, Dubey T, Mulani FA, Thulasiram HV And Subashchandrabose Chinnathambi*. , Basic Limonoid modulates Chaperone-mediated Proteostasis and dissolve Tau fibrils, Scientific Reports, Nature Group., , (2020), DOI:doi: 10.1038/s41598-020-60773-1.
  • Smita Eknath Desale and Subashchandrabose Chinnathambi*, Dietary fatty acids influence microglial phagocytosis to clear the extracellular Tau in Alzheimer’s disease, Journal of Neuroinflammation., , (2020), DOI:Proof.
  • Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*, G-Protein Coupled Receptors and Tau-Different roles in Alzheimer’s disease, Neuroscience., , (2020), DOI:Accepted, NSC-19-1683.
  • Abhishek Balmik@ And Shweta Sonawane@ and Subashchandrabose Chinnathambi*, Modulation of Actin network and Tau phosphorylation by HDAC6 ZnF UBP domain, BioRXiV and Cellular and Molecular Neurobiology., , (2020), DOI:doi: https://doi.org/10.1101/702571, CEMN-D-20-00055R1.
  • Nalini Vijay Gorantla And Ekambaram Balaraman and Subashchandrabose Chinnathambi*., Cobalt-based metal complexes prevent the aggregation of Repeat Tau in Alzheimer’s disease, International Journal of Biological Macromolecules., , (2020), DOI:doi: 10.1016/j.ijbiomac.2020.02.278.
  • Abhishek A Balmik, Rashmi Das, Abha Dangi, Udaya Kiran Marelli And Subashchandrabose Chinnathambi*., Melatonin Interacts with Repeat Domain of Tau to Mediate Disaggregation of Paired Helical Filaments, BBA, General Subjects., 1864 (3), 129467 (2020), DOI:doi: 10.1016/j.bbagen.2019.129467.
  • Rashmi Das# And Abhishek Ankur Balmik# and Subashchandrabose Chinnathambi*, Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology, International Journal of Biological Macromolecules., , (2020), DOI:doi: 10.1016/j.ijbiomac.2020.01.296.
  • ShwetaKishor Sonawane and Subashchandrabose Chinnathambi*. , A green tea polyphenol Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network, Under Review., , (2019).
  • Nalini Vijay Gorantla, Rashmi Das And Ekambaram Balaraman* and Subashchandrabose Chinnathambi*, Transition metal nickel prevents Tau aggregation in Alzheimer’s disease, International Journal of Biological Macromolecules., , (2019), DOI:doi: 10.1016/j.ijbiomac.2019.11.176.
  • Shweta Sonawane#, Abhishek Balmik#, Debjyoti Boral And Sureshkumar Ramasamy and Subashchandrabose Chinnathambi*, Baicalein suppresses Tau fibrillization by sequestering oligomers, Archives of Biochemistry and Biophysics, Review and Published in BioRxiv doi: https://doi.org/10.1101/704536., 675, 108119 (2019), DOI:https://doi.org/10.1016/j.abb.2019.108119; BioRxiv doi: https://doi.org/10.1101/704536.
  • Tushar Dubey and Subashchandrabose Chinnathambi*. , Brahmi (Bacopa monnieri): An Ayurvedic herb against the Alzheimer’s disease, Archives of Biochemistry and Biophysics, review., , (2019), DOI:doi: 10.1016/j.abb.2019.108153.
  • COVER PAGE: Tushar Dubey, Nalini Vijay Gorantla, Kagepura Thammaiah Chandrashekara And Subashchandrabose Chinnathambi*., Photo-excited Toluidine blue inhibits Tau aggregation in Alzheimers disease, ACS Omega., 4 (20), 18793 - 18802 (2019), DOI:DOI 10.1021/acsomega.9b02792.
  • COVER PAGE: Rashmi Das and Subashchandrabose Chinnathambi*. , Microglial Priming of Antigen Presentation and Adaptive Stimulation in Alzheimer’s disease, Cellular and Molecular Life Sciences., doi: 10.1007/s00018-019-03132-2, (2019), DOI:https://doi.org/10.1007/s00018-019-03132-2 (2019).
  • Shweta Sonawane and Subashchandrabose Chinnathambi*, Protein Capped Metal Nanoparticles Inhibit Tau Aggregation in vitro, ACS Omega, Chem RXiV, https://doi.org/10.26434/chemrxiv.8208026.v1., 7, 12833 - 12840 (2019).
  • Nalini Vijay Gorantla, Vinod Ganesh Landge, Pramod G Nagaraju, Poornima Priyadarshini, Balaraman Ekambaram* And Subashchandrabose Chinnathambi*, Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer’s Disease, ACS Omega, BioRxIV (doi.org/10.1101/363572)., , (2019), DOI:doi.org/10.1021/acsomega.9b00692.
  • Nalini V. Gorantla, Rashmi Das, Fayaj A. Mulani And Hirekodathakallu V. Thulasiram* and Subashchandrabose Chinnathambi*, Neem derivatives inhibits Tau aggregation, Journal of Alzheimer's Disease Reports., 3, 169 - 178 (2019), DOI:DOI 10.3233/ADR-190118.
  • Nalini Vijay Gorantla and Subashchandrabose Chinnathambi*., Tau Protein Squired by Molecular Chaperones during Alzheimer’s Disease, Journal of Molecular Neuroscience (Springer)., 2018 Nov;66(3), 356 - 368 (2018).
  • Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*., Prion-like Propagation of Post-translationally Modified Tau in Alzheimer’s Disease, Journal of molecular Neuroscience, Springer., , 1 - 11 (2018), DOI:10.1007/s12031-018-1111-5.
  • Abhishek Balmik and Subashchandrabose Chinnathambi*, Multi-faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer`s Disease, Journal of Alzheimer's Disease (JAD))., 2018;62(4):1481-1493, (2018).
  • Nalini Vijay Gorantla, Puneet Kandelwal And Pankaj Poddar and Subashchandrabose Chinnathambi*., Microtubule-Associated Protein-Tau Conformation Mapped by Raman Spectroscopy, Methods in Molecular Biology (MiMB- Tau Protein) Springer Publications., , (2017).
  • Nalini Vijay Gorantla, Alexander V. Shkumatov And and Subashchandrabose Chinnathambi*., Conformational Dynamics of Intracellular Tau Revealed by Circular Dichorism and SAXS, Methods in Molecular Biology (MiMB- Tau Protein) Springer Publications., , (2017).
  • Batkulwar KB, Bansode SB, Patil GV, Godbole RK, Kazi RS, Chinnathambi Subashchandrabose, Shanmugam D And Kulkarni MJ, Investigation of Phosphoproteome in RAGE signaling, Proteomics., October, (2015), DOI:10.1002/pmic.201400169.
  • Coppola*, Chinnathambi Subashchandrabose*, et al. And , Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer’s disease, (First Author) - Human Molecular Genetics (HMG)., 21(15), 3500 - 3512 (2012), DOI:10.1093/hmg/dds161.
  • Sadasivam J*, Chinnathambi Subashchandrabose*, Mandelkow Eva., and Mandelkow And E, Conformations of Microtubule-Associated Protein Tau mapped by fluorescence resonance energy transfer (FRET), First Author, Book Chapter - Methods in Molecular biology (Amyloid Proteins)., 849, 85 - 99 (2012), DOI:10.1007/978-1-61779-551-0_7.
  • Daebel V, Chinnathambi Subashchandrabose #, Biernat J, Schwalbe M, Habenstein B, Loquet A, Müller H, Baldus M, Griesinger C, Zweckstetter M, Mandelkow E, Vijayan V And Lange A., Beta - Sheet core of tau paired helical filaments revealed by solid-state NMR, Journal of American Chemical Society (JACS)., 134(34), 13982 - 13989 (2012), DOI:10.1021/ja305470p.
  • Shkumatov, A.V*., Chinnathambi Subashchandrabose*., Mandelkow, E., and Svergun And D.I, Structural memory of natively unfolded Tau protein detected by small-angle X-ray scattering (SAXS), First Author, Proteins., 79, 2122 - 2131 (2011), DOI:10.1002/prot.23033.
  • Stefan B , Marco DM , Chinnathambi Subashchandrabose, Jacek B, Christian Griesinger , Eckhard Mandelkow And and Markus Zweckstetter , The Dynamic Structure of Filamentous Tau, Angewandte Chemistry, International Edition., 50, 11520 - 11524 (2011), DOI:10.1002/anie.201105493.
  • Wegmann, S., Jung, Y.J., Chinnathambi Subashchandrabose#., Mandelkow, E.M., Mandelkow, E., and Muller And D.J., Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability, COVER PAGE ARTICLE - Journal of Biological Chemistry (JBC)., 285, 27302 - 27313 (2010), DOI:10.1074/jbc.M110.145318.
  • Pappachan, A., Chinnathambi Subashchandrabose#, Satheshkumar, P.S., Savithri, H.S., and Murthy And M.R., A single point mutation disrupts the capsid assembly in Sesbania Mosaic Virus resulting in a stable isolated dimer, COVER PAGE ARTICLE - Virology., 392, 215 - 221 (2009), DOI:10.1016/j.virol.2009.06.047.
  • Pappachan, A., Chinnathambi Subashchandrabose#, Satheshkumar, P.S., Savithri, H.S., and Murthy And M.R., Structure of recombinant capsids formed by the beta-annulus deletion mutant rCP (Delta48-59) of Sesbania mosaic virus, COVER PAGE ARTICLE - Virology., 375, 190 - 196 (2008), DOI:10.1016/j.virol.2008.01.023.
  • Jeganathan, S., Hascher, A., Chinnathambi Subashchandrabose, Biernat, J., Mandelkow, E.M., and Mandelkow And E., Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation, Journal of Biological Chemistry (JBC)., 283, 32066 - 32076 (2008), DOI:10.1074/jbc.M805300200.
  • Tazeen Qureshi and Subashchandrabose Chinnathambi*., Histone Deacetylase-6 modulates Tau Function in Alzheimer’s Disease, Cell Communication & Signaling., , (0000), DOI:Revision.