Research Group Members 

Dr. Subashchandrabose Chinnathambi (Subash)

Assistant Professor AcSIR and Senior Scientist,

Neurobiology Group

Biochemical Sciences Division, CSIR-National Chemical Laboratory

Pune – 411 008, INDIA

Email: s.chinnathambi@ncl.res.in ; bosesd@gmail.com

Tele (office): 020-2590-2232

         (lab): 020-2590-2227

Fax: 020-2590-2648

https://sites.google.com/view/sbclab/home 

Graduate Students

 

Tushar Dubey, (Tushar) Ph.D., Student (UGC-SRF), August, 2015

M. Sc. Microbiology, Pune University, Pune, Maharasthra.

Email: ta.dubey@ncl.res.in

Interest of our work is to study the signaling cascades of Tau in Alzheimer's disease. The down regulation of many signaling cascades like nuclear transport has been reported in Alzheimer's disease. The main area of our study is to understand the molecular mechanisms of RAN GTPase with Tau. We are also interested in studying the interaction of CDK5/p25 complex in context of Tau pathology and the effect of novel peptide molecules for regulating the hyper- phosphorylation of Tau. Various biochemical, biophysical and microscopic analyses are being regularly carried out in lab for validating our hypothesis.

I have two passions in my life one is for science and other is for good food, If you don’t find me in lab you can check me in some good restaurant.

 

Rasmi Das, (Roushmi) Ph.D., Student (UGC-SRF), August, 2017.

M. Sc. Biotechnolgy, University Of Calcutta, Kolkata, West Bengal.
Email: r.das@ncl.res.in

The heterogeneous Tau oligomers are one of the pathological concerns in the Alzheimer’s Disease (AD). Oligomers are the key players in the disease propagation, synaptic loss and neuronal toxicity. In this context, we want to study the role of microglia either for protection or disease propagation in AD. We are also interested to find out the interaction of some trans activator with Tau.

Apart from Science, my interest is in Indian classical dance forms.

 

Smita Eknath Desale, (Smita) Ph.D., Student (DBT-SRF), August, 2018-

M. Sc.Biotechnology, Mumbai University Mumbai.

Email: se.desale@ncl.res.in

Dietary fatty acids have major influence on brain especially omega-3 fatty acids. They have ability to change the functionalities of brain cells majorly microglia cells. In this study we try to check the effect of omega -3 fatty acids on microglial phenotype. The fatty acids would convert microglia cells towards M2 phagocytic microglia, in this study we would like to check the markers, expression profile of M2 microglia and its role in reducing Tau propagation in Alzheimer’s disease.

Other than science my interests are travelling, trekking, reading.

  

Hariharakrishnan Chidambaram, (Hari), Ph.D., Student (DBT-SRF), August 2018.

B. Tech. Biotechnology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu.

Email: ch.krishna@ncl.res.in

Phosphorylation of Tau makes the protein prone to aggregation at the intra-neuronal region leading to impaired neuro-transmission and dementia. In Alzheimer’s disease, G-Protein Coupled Receptors (GPCRs) are involved in phosphorylation of Tau through various down-stream kinases such as GSK-3β and ERKs. We are interested to know the signalling cascades involved in Tau phosphorylation. We are also interested to know about the direct interaction of Tau with GPCRs.

My other interests include adventure travels and sight seeing. 

 

Tazeen Qureshi (Tazeen), Ph.D. student (DST-INSPIRE), August 2020-

M.Sc. Biophysics, Mumbai University, Mumbai.

Email: t.qureshi@ncl.res.in

Histone Deacetylase 6 is a unique HDAC in that it performs numerous cytoplasmic functions. It interacts with many different molecules in the cell and its entire potential hasn't been fully tapped into. From the preliminary studies in the lab, HDAC6 has been observed to modulate the aggregation properties of Tau protein. Our interest lies in understanding the mechanism of these modulation effects in-vitro as well as within neurons.

Reading, music and travelling are among my other interests.

 

Mahima Kapoor, (Mahima), January 2021.

TGFβ is a pleiotropic cytokine known to partake in neuroprotective and immunoregulatory functions in the brain. We are trying to understand the role of TGFβ signalling in microglia-mediated targeting of extracellular tau, expelled as the result of prion-like propagation of pathoproteins in Alzheimer’s disease. Furthermore, we are also interested in determining the major players in TGFβ-triggered cytoskeletal reorganization in microglia. 

I am a true-crime/psychological-thriller movie buff, an avid reader, and a logophile with mild sesquipedalian tendencies. When not in the lab, I love singing, trekking, and exploring local culture-cuisine.

 

Aashima Jain, (Aashima), August 2021.

 

Ankita Namdeo, (Ankita), January 2022.

 

Graduate Students Alumni

 

Abhishek Ankur Balmik, Ph.D. (January 2015 - June 2021) 

Affliation after leaving our lab:

 

Shweta Kishor Sonawane, Ph.D. (January 2014 - January 2021)

Affliation after leaving our lab:

Institute of Neuropathiphysiology

CNRS - Aix-Marseille University

Marseille, France

 

Nalini Vijay Gorantla, Ph.D. (January 2014 - January 2021)

Affliation after leaving our lab:

 

 

Research Fellows and assistants

 

Ms. Tanuja Sarkar, Project assistant (DBT-Neuroscience)

M. Sc. Neuroscience (DBT), Jiwaji University, Gwalior, Madhya Pradesh.

Mrs. Lisni Sunny, Project assistant (DST-SERB)

M. Sc. Biochemistry, Bharathiyar University, Coimbatore, Tamil Nadu.


Alumni

Ms.  Umamaheshwari Kadambari, M.Sc Intergrated Biotechnology, Bharathidasan University, Trichy, Tamilnadu.

Mr.  Dhyey Vyas, M.Sc Intergrated Molecular Biology, M S Baroda University, Baroda, Gujarat.

Mr. Abhibroto Karmakar, M.Sc Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, West Bengal.

Mr. A. Arokeyamychealsimon, M.Sc Biotechnology, Bharathiyar University, Coimbatore, Tamil Nadu.

Mr. Gopi VK, M.Sc Biotechnology, Bharathiyar University, Coimbatore, Tamil Nadu.

Mr. Palgun Raj, M.Sc Human Genetics, Andhara University (AU), Visakhapatnam, Andhara Pradesh.

Ms. Ragini Agarwal, M.Sc Biotechnology, Madurai Kamraj University (MKU), Tamilnadu.

Mr. Sayan Das, M.Sc Intergrated Molecular Biology, Mysore University, Karnataka.

Ms. Niveditha, M.Sc Biotechnology, Sastra University, Tamilnadu.

Ms. Urvi Goyal, M.Sc Biotechnology, Mata Gujri Mahila Rani Durgavati University, Madhya Pradesh.

Ms. Anjhu Nair, M.Sc Animal Science, Bharathidasan University , Tamilnadu.

Mr. Gokul Raja, M.Sc Biotechnology, Bharathiyar University, Tamilnadu.

Ms. Namrata Pai, M.Sc Medical Genetics, VIT University, Tamilnadu.

Ms. Ankita Ray M.Tech Biotechnology, VIT University, Tamilnadu.

Mr. Kunal Gode, M.Tech Biotechnology, VIT University, Tamilnadu.

Ms. Ananya Dey, M.Sc Biotechnology, Mumbai University, Maharasthra.

 

Neuroscience

http://www.alzforum.org/     (Alzheimer’s research forum)

http://neuroscienceacademy.org.in/index.php

http://www.neurosocietyindia.com/Fellowships.aspx

http://multalin.toulouse.inra.fr/multalin/multalin.html  (Protein structure prediction)

http://indiabioscience.org/yim   (YIM - Indian Bioscience)

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Way to share/bring your plasmids

https://www.addgene.org/

Kinesin Home page

http://labs.cellbio.duke.edu/Kinesin/KinesinPeople.html

Cytoskeletal lab home page

http://www.bms.ed.ac.uk/research/others/smaciver/Cytoskeletal%20Labs.html